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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials
منشور في 2025"…</p><h3>Conclusions</h3><p dir="ltr">Silver-based dressings reduce the risk of SSIs significantly; however, further high-quality RCTs are needed to confirm their benefits across different surgical contexts and patient populations.…"
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Trends in Necrotizing Fasciitis‐Associated Mortality in the United States 2003–2020: A CDC WONDER Database Population‐Based Study
منشور في 2025"…</p><h3>Conclusions</h3><p dir="ltr">NF‐related mortality has significantly risen in the United States since 2014, with distinct disparities based on sex, race, and geographic region. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Impact of timing and severity of COVID-19 infection in pregnancy on intrauterine fetal growth- a registry-based study from Doha-Qatar
منشور في 2023"…Women in the second trimester were significantly younger and symptomatic. Women infected in the first trimester were least likely to have diabetes. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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SARS‐CoV‐2 infection triggers more potent antibody‐dependent cellular cytotoxicity (ADCC) responses than mRNA‐, vector‐, and inactivated virus‐based COVID‐19 vaccines
منشور في 2024"…All evaluated vaccine platforms are inferior in inducing ADCC compared to natural infection with WT SARS‐CoV‐2. The inactivated virus‐based vaccine can induce N‐specific ADCC activity, but its relevance to clinical outcomes requires further investigation. …"
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Hepatitis C infection epidemiology in Mongolia: protocol of a systematic review and meta-analysis
منشور في 2017"…Additionally, we aim to estimate national population-level HCV-Ab prevalence and the number of HCV chronically infected individuals in the population of Mongolia.…"
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Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients
منشور في 2003"…Twenty-five (32.5%) samples showed mixed genotype infections. Single genotype distribution was significantly different among dialysis and non-dialysis patients. …"
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Efficient and cost-effective alternative treatment for recurrent urinary tract infections and interstitial cystitis in women
منشور في 2016"…Urinary tract infections (UTIs) are among the most common bacterial infections affecting women. …"
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Plasma Bead Entrapped Liposomes as a Potential Drug Delivery System to Combat Fungal Infections
منشور في 2022"…<div><p>Fibrin-based systems offer promises in drug and gene delivery as well as tissue engineering. …"