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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Cybersecurity Transparency and Firm Success: Insights From the Australian Landscape
منشور في 2024"…To the best of our knowledge, this study stands out as one of the limited inquiries examining the impact of cybersecurity disclosure on company performance, specifically within the Australian context. The insights derived from this research carry significance for regulators, policymakers, investors, lenders, and a diverse array of stakeholders. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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On the molecular properties of graphene-pyrazines conjugated Ru and Fe complexes: Computational insights
منشور في 2020"…Graphene and related materials can exhibit substantial molecular properties of significant importance in various landscapes of interests including catalysis. …"
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On the molecular properties of graphene-pyrazines conjugated Ru and Fe complexes: Computational insights
منشور في 2021"…<p dir="ltr">Graphene and related materials can exhibit substantial molecular properties of significant importance in various landscapes of interests including catalysis. …"
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Insights into rechargeable Zn-air batteries for future advancements in energy storing technology
منشور في 2023"…Therefore, this review provides significant insights into the fundamentals of Zn air battery system in terms of the underlying electrochemical mechanism, composition/structural performance relationship of different battery components. …"
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When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial
منشور في 2021"…Univariate analysis showed a significant increase in the frequency of epileptogenic lesions with decreasing age, the presence of developmental delay, and the number and types of seizures at presentation. …"
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