A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

"…Further, analysis of trajectories for <u>hydrogen bonds</u> (H-bonds) formed between NLuc and furimazine revealed substantial H-bond interaction between R162 and Q32 residues. Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …"

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. By elucidating a mechanistic basis for the increased affinity of the N501Y mutant S1-RBD for ACE2, we believe that the results presented here will aid in developing therapeutic strategies against SARS-CoV-2 including designing of therapeutic agents targeting the ACE2-S1-RBD interaction.…"

The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"

The Effect of the Variation of the Modulus of Subgrade Reaction on the Design of Large Shallow Foundations حسب Al Kaaby Al Zoaby, Hassan

"…With the use of variable coefficient across the mat foundation, a significant decrease in the steel reinforcement is witnessed and an optimized/ more adapted steel distribution is observed.…"
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Release of colloids in saturated porous media under transient hydro-chemical conditions: A pore-scale study حسب Safna Nishad (16932474)

"…<p dir="ltr">The deposition and consequent release of colloids pose a significant challenge to the environment, groundwater quality and human health. …"

Hemodynamics of small aneurysm pairs at the internal carotid artery حسب Jou, Liang-Der

"…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.…"
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Dynamic Properties of Water Confined in Graphene-Based Membrane: A Classical Molecular Dynamics Simulation Study حسب One-Sun Lee (1291293)

"…The translational diffusion coefficient along the graphene surface increases as the number of water molecules in the droplet decreases, because the bigger water droplet has a stronger van der Waals interaction with the graphene surface that hampers the translational motion. …"

Pore-scale simulation of fine particles migration in porous media using coupled CFD-DEM حسب Ahmed Elrahmani (17128837)

"…The time required to develop bridging and subsequent clogging of the pore space that lead to permeability reduction decreases as the flow velocity increases. The size of the fine particles has a significant impact on permeability reduction where the reduction in permeability increases as the size of particles increases. …"

Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk حسب Merhi, Mahmoud

"…Moreover, a significant smoking-gene interaction is determined with CYP1A1 MspI polymorphism rs4646903 and is associated with a decreased risk of CAD in current smokers (OR 0.52137). …"
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Social Media Use and Body Checking Among Lebanese Adults حسب Korkomaz, Aya

"…However, self-esteem, gender, and the number of online friends and their interaction with them lost significance. Additionally, the most significant variable in explaining the variation in body checking was emotional eating. …"
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines حسب Ismail, Jana

"…The combination of CBD with either cisplatin or paclitaxel exhibited a significant antagonistic interaction against SK-OV-3 cell line when compared to individual treatment (CI > 1). …"
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Sustainable Detoxification of Methylene Blue in Wastewater via Tea Residue Adsorption: Optimization and Kinetics حسب Farah F. Salameh (21797300)

"…The Sips model confirms significant heterogeneity. The Temkin model, which assumes that the heat of adsorption decreases linearly with coverage due to adsorbent-adsorbate interactions, aligns strongly with the data. …"

Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice حسب Zeeni, N.

"…When comparing diet effects, while the HF diet did not induce any change in activity, reductions in MEMRI-associated signal were found in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) when comparing the HP to the HC diet. In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. …"
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DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation حسب Abdelilah Arredouani (10914455)

"…In co-immunoprecipitation assays, DNAJB3 interacts with both JNK1 and IKKβ kinases. However, the functional impact of such interaction on their activities has not been investigated. …"

Why do some countries produce more capital intensive output than others? حسب Toukan, Amjad

"…In my game theoretic analysis I model the interaction between firms and corrupt government officials as a contest while allowing for international variability in the quality of governance. …"
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Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling حسب Khalifeh, Mohamad Rabieh

"…Even though initially, WTS decreased anxiety-like behaviors it was found that prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. …"
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Disrupted harvests: how Ukraine – Russia war influences global food systems – a systematic review حسب Hamid El Bilali (15864930)

"…This systematic study delves into this intricate interaction, examining scholarly literature to determine the magnitude and complexities of the war’s impact on global agri-food systems. …"

Intravenous administration of gold nanoparticles in rats exhibit alterations in sphingomyelins, bile acids, sphingolipids, and cholesterol esters levels حسب Haya Al-Sulaiti (5449256)

"…<p dir="ltr">Nanoparticles (NP) have gained significant attention in biomedical research due to their unique properties and potential applications in drug delivery, imaging, and diagnostics. …"

Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications حسب Sumama Nuthana Kalva (17302906)

"…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"

Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling حسب Khalifeh, Mohamad

"…Even though WTS initially decreased anxiety-like behaviors, prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. …"
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