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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Swelling-induced twisting and shearing in fiber composites: the effect of the base matrix mechanical response
منشور في 2019"…As we describe here, it is this shear response that governs the matrix contribution to the twist-swelling interaction. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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A Decision Modelling Approach for Perceived and Engaged Immersive Visual Interactive Applications on the Metaverse
منشور في 2024"…The modelling approach benchmarks the most perceived immersive visual interactive applications using the extended VIKOR-GRA method based on a decision matrix of 18 criteria and 29 alternatives for the four visualization scenarios. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Insights into the interaction between mineral formation and heavy metals immobilization, mediated by Virgibacillus exopolymeric substances
منشور في 2024"…Heavy metal pollution poses significant risks to both the environment and human health due to their toxicity, long residence times, and their ability to bioaccumulate and bio magnify across the food chain. …"
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Machine Learning Techniques for Pharmaceutical Bioinformatics
منشور في 2018"…This dissertation presents a novel drug classifier to automate the prediction of drug indication and drug interactions with other drugs. The study integrates knowledge visualization, analysis, as well as development of a predictive model based on the Drug-Drug Interactions (DDIs) as a complex network. …"
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Transcriptomic profiling and bioinformatics-driven statistical prioritization of CRC biomarkers: A step toward precision oncology
منشور في 2025"…Functional enrichment analysis linked these genes to extracellular matrix degradation, epithelial-mesenchymal transition (EMT), inflammatory signaling, and tumor invasion, underscoring their roles in key oncogenic processes. …"
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Analysis of the Capacitor-Less D-STATCOM for Voltage Profile Improvement in Distribution Network With High PV Penetration
منشور في 2022"…The contribution of this paper is a detailed analysis and impact study of the capacitor-less D-STATCOM in high PV penetration distribution networks. The significance of this paper is that it studies the behavior of the power electronics converter and its interaction with the power systems without assuming or neglecting details of either. …"
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
منشور في 2017"…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …"
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
منشور في 2017"…It is estimated that a 10% increase in the share of renewable energy could decrease CH4 emissions by about 0.26%. …"
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
منشور في 2020"…However, only in lower dose of sumac were significant decreases in the expression of oncogenic miR210 and increase of tumor-suppressive miR145 (miR21, miR22, and miR155 were not changed) observed. …"