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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Designing a Flexible and Reconfigurable Manufacturing System Considering a Circular Shaped Layout
منشور في 2018احصل على النص الكامل
doctoralThesis -
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Effects of the Phantom Shape on the Gradient Artefact of Electroencephalography (EEG) Data in Simultaneous EEG–fMRI
منشور في 2018"…Moreover, a paired t-test showed that the head-shaped phantom’s and the spherical phantom’s data were significantly different (p < 0.005) from the subjects’ data, whereas the difference between the head-shaped phantom’s and the spherical phantom’s data was not significant (p = 0.07). …"
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Double diffusive mixed convection and entropy generation analysis of NEPCM-water mixture in a π-shaped cavity
منشور في 2025"…This study aims to investigate double-diffusive mixed convection and entropy generation in a π-shaped cavity with wavy lid containing NEPCM-water mixture subjected to a transverse magnetic field. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Binge-Watching Serial Video Content: Exploring the Subjective Phenomenology of the Binge-Watching Experience
منشور في 2020"…The results underscore the centrality of transportation in shaping viewers’ perceptions of the binge-watching experience and their binge-watching behaviors. …"
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Copper (I) oxide nanocubes loaded with a low-content binary PtIr alloy enable enhanced methanol/ ethanol oxidation
منشور في 2025"…<p dir="ltr">The design of a catalyst plays a significant role in developing high-performance renewable energy materials. …"
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Exploring the Impact of Social, Cultural, and Science Factors on Students’ STEM Career Preferences
منشور في 2024"…The key findings revealed a significant interaction effect between gender and gender-related job preferences. …"
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The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer
منشور في 2020"…HuArgI (Co)-PEG5000 is a potential drug to target cancers that depend on exogenous sources of arginine and cannot synthesize their own. In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
masterThesis -
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Assessing Factors Influencing Customers’ Adoption of AI-Based Voice Assistants
منشور في 2024"…Besides this, the findings reclaim that “reasons” (for/against) shape to form the attitude of consumers toward voice assistants. …"
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The Effect of Recombinant Anthrax Lethal Toxin on Breast Cancer Cell Motility, Adhesion, and Invasion
منشور في 2020"…Cells treated with LT showed a significant decrease in motility as seen in 2D time-lapse and wound healing assays. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
masterThesis -
20