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Treating Cancers Using Nature’s Medicine: Significance and Challenges
منشور في 2021"…With the advent of science-based ‘modern’ medicine, plant-based natural remedies for treating ailments came under intense scrutiny for their lack of scientific basis [1]. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
منشور في 2021"…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Effectiveness of a Technology-Based Intervention to Teach Evidence-Based Practice: The EBR Tool
منشور في 2016"…Background As the world becomes increasingly digital, advances in technology have changed how students access evidence-based information. Research suggests that students overestimate their ability to locate quality online research and lack the skills needed to evaluate the scientific literature. …"
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Effect of Qatar-based law amendment on pedestrians’ behavioral intentions: A PLS-SEM based analysis
منشور في 2024"…To assess the efficacy of such enforcements, pedestrian sentiments towards these law enforcements need to be determined. There is a general lack of studies assessing the effect of pedestrian law enforcement on pedestrians’ behavior. …"
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The reasons behind the non-application of the activity based costing system in the service industry in Lebanon. (c2015)
منشور في 2015"…Other factors sum up as the priority of company to other considerations, and the lack of technology.…"
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Additive Manufacturing of Polymer/Mg-Based Composites for Porous Tissue Scaffolds
منشور في 2022"…Due to their mechanical strength and biocompatibility, metal-based scaffolds have been used for various bone regenerative applications. …"
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Investigating the Effectiveness and Teachers’ Perceptions of Rigorous Curriculum Design for Project-Based Learning Implementation on Middle School Science Students’ Achievement and...
منشور في 2023"…Background and Purpose: Project-based learning (PBL) is an active student-centered instructional that has been explored in various contexts of schooling over the years. …"
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