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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Customer Service and Satisfaction in the three main Airports of the United Arab Emirates
منشور في 2007"…Based on that, 5 main criteria were set that had to be met and continuously achieved by the aviation industry in the UAE. …"
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Detection of statistically significant network changes in complex biological networks
منشور في 2017"…</p><h3>Methods</h3><p dir="ltr">In this paper, we propose an improvement over the state-of-the-art based on the Generalized Hamming Distance adopted for evaluating the topological difference between two networks and estimating its statistical significance. …"
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The Grid Iron Patterns & Detached Villas as the Main Drivers of Sharjah City’s Urban Sprawl
منشور في 2021"…On the demographic side, the massive external population migration that trickled towards the city resulted in a major defect in its demographic structure, which represented a decrease in the percentage of the citizen population to only about 10% of the non-citizen population. …"
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A Multidecadal Assessment of Haze Development and Fluctuations in Visibility for Arabian Peninsula
منشور في 2024"…To comprehend the time-based patterns of visibility across the ME, we utilized the Mann Kendall (MK) and Modified Mann Kendall (MMK) trend estimators in both space and time. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Hydrogen energy systems: Technologies, trends, and future prospects
منشور في 2024"…This comprehensive approach will ensure that hydrogen energy can significantly contribute to a sustainable and low-carbon future.…"
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Enhancing the Main Contractor-Subcontractor trusting relationship in the United Arab Emirates: A strategic approach to rebuilding trust in complex construction projects
منشور في 2017"…The researcher found that trust factor has a significant impact on subcontractors and main contractors’ relationship, however, there is minor impact of their relationship on building trust between them, and that early contractor engagement in the initiation and planning stage positively impacts the subcontractors and main contractors’ relationship, and that the higher the level of trust between them, the better the project performance. …"
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Studying the impact of an energy retrofit of a UAE-based existing building by adding intelligent valves on the main chilled water risers and reconfigure the chilled water pumps to...
منشور في 2021"…With that being said, this research aims to provide reliable information and outputs on the best practice of operating chilled water network for a UAE-based building by converting the constant primary network to a variable one in addition to solve permanently the building ΔT issues by replacing the conventional pressure dependent control valves and adding intelligent valves on the main risers and the main airside equipment for this selected building, aiming to be quite practical as could as possible and have the outcome of combining both measures together, accordingly, the results show a potential energy saving on the range of 14-21% on the conservative side by applying the suggested retrofit measures, which leads to approximately an energy cost of savings of at least half a million to seven hundred thousands of UAE dirhams along with simple payback of 3-4 years which is considered an attractive SPB period for investors on such fields. …"
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A Novel Steganography Technique for Digital Images Using the Least Significant Bit Substitution Method
منشور في 2022"…Therefore, the proposed work, in this paper, is based on the Least Significant Bit (LSB) substitution method. …"
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Antibiotic use and escherichia coli resistance trends for quinolones and cotrimoxazole in Sweden
منشور في 2002"…Cotrimoxazole resistance has also been increasing significantly in most hospitals, in spite of decreasing sales of cotrimoxazole and trimethoprim. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Trends of the Dementia Burden in South Asia: An Analysis of 2021 Global Burden of Disease Study
منشور في 2025"…</p><h3>Results</h3><p dir="ltr">A slight decrease in incidence rates from 80.57 to 79 per 100,000 was observed, alongside a significant increase in mortality rates from 14.11 to 17.2 per 100,000. …"