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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Causes of construction reworks and their mitigation strategies
منشور في 2018"…Main causes of works reputation are poor project management team, less manpower and non-maintained construction machinery, country political situation, Week project documents, stakeholders and communication problems and weak commination between project team. …"
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Construction Disputes in the UAE: Causes and Resolution Methods
منشور في 2020"…Claims and disputes occur frequently in the construction industry between different contracting parties, mainly the owner, the designer and the contractor. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Developing a Stochastic Model to Predict Cost Overrun due to the Causes of Projects Delay in Oil Fields Construction Industry
منشور في 2020"…The main aim of the research is to establish a model that could be used to map the causes of projects delay to the cost overrun in oil fields construction projects and to investigate the variables that contribute to budget/cost overrun. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Optimization of p-chart for Processes with Multiple Assignable Causes and Random Shift
منشور في 2020احصل على النص الكامل
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Investigating the Causes of Food Waste in the Hospitality Sector in Dubai-UAE. Toward Implementing Food Waste Prevention Strategies
منشور في 2025"…It found that customers’ main causes of FW were taking big portions and lack of awareness. …"
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An Exploration of the Causes of Cost Overruns in Public Sector Infrastructure Projects in the United Arab Emirates (UAE): A Stakeholder Perspective
منشور في 2017"…Therefore, this proposed dissertation is investigating the factors that cause costs to overrun in public sector infrastructure projects specifically in UAE from perspective of clients and contractors as well as consultants who are the main three stakeholders. …"
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Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
منشور في 2021"…VISTA and AHR levels were assessed by qPCR, Western blot, immunofluorescence microscope, flow cytometry, and immunohistochemistry. Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. …"
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