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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Simulation Based Optimization of Logistics Decisions Under Horizontal Collaboration
منشور في 2023احصل على النص الكامل
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Claims Management and Substantiation in the United Arab Emirates Construction Sector
منشور في 2012"…Some of the findings revealed in this dissertation were the importance of records keeping, formal notifications and significance of change and change orders in the context of claims management and other key aspects relevant to the field of claims management and substantiation.…"
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A Novel Steganography Technique for Digital Images Using the Least Significant Bit Substitution Method
منشور في 2022"…Therefore, the proposed work, in this paper, is based on the Least Significant Bit (LSB) substitution method. …"
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What is the impact of implementing problem-based learning (PBL) in school curricula on the development of critical thinking abilities in elementary students?
منشور في 2025"…This study examines the effect of implementing Problem-Based Learning (PBL) in elementary school curricula on the development of critical thinking skills among students. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Optimisation of PV Cleaning Practices: Comparison Between Performance Based and Periodic Based Approaches
منشور في 2018"…Adaptive periodic based manual cleaning approach where a changing cleaning period is fixed for each season based on significant variations of seasonal averages from the performance based manual cleaning approach, taken as 1 standard deviation from the season average. 3. …"
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The Impact of Inquiry-based Learning on the Critical Thinking of high School Students
منشور في 2021"…Explanatory sequential mixed-methods approach was utilized in the current study in which the data are collected and analyzed quantitatively first, and then qualitative data were collected in order to fully explain the quantitative data results The current study found that inquiry-based learning approach has a statistically significant positive impact on the high school students’ critical thinking in where the independent T-test results were for t (90) = 7 with a P value equals to 0.000 ˂ 0.05. …"
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LCMV-Based EEG & FNIRS-Based Brain Source Localization of Mental Stress
منشور في 2024احصل على النص الكامل
doctoralThesis