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Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene
منشور في 2004"…Several genetic loci have been implicated in the susceptibility to this illness. Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Ratio between positive lymph nodes and total excised axillary lymph nodes as an independent prognostic factor for overall survival in patients with nonmetastatic lymph node-positiv...
منشور في 2009"…On univariate analysis, both the absolute number of positive lymph nodes and the ALNR were significant predictors of OS. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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The Impact of Adopting Positive Education and Wellbeing Culture on Learners with Special Educational Needs and Disabilities (SEND) in a Private and Mainstream School in Dubai: An E...
منشور في 2020"…While it has been demonstrated that the role of positive education and wellbeing culture is vital to the optimal development of students within school settings, scrutiny and reluctance to employ novel techniques present a significant challenge and a never-ending list of “to-dos” that hinder the opportunity to ensure an ideal school environment. …"
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Positive Epstein-Barr virus polymerase chain reaction in a case of acute retinal necrosis
منشور في 2012"…Epstein-Barr virus (EBV) is a ubiquitous DNA virus of the Herpesvirus genus. Its role in the pathogenesis of ocular disease is still controversial. …"
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The Role of Media Literacy in Countering Misinformation
منشور في 2023"…Results indicate a significant positive association between youth media exposure and them believing in COVID-19 conspiracy theories. …"
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Migration and Net FDI: Role of Governance
منشور في 2024"…The result revealed that 78% of net FDI comes from migrants and structure governance of hosted countries. Particularly, positive relationship between migration and FDI was significantly stronger at a higher level of governance. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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The role of institutional quality in reducing environmental degradation in Canada
منشور في 2024"…Moreover, our findings indicated that there is a statistically significant and positive impact of income on CO<sub>2</sub> emissions, while trade openness exhibits an insignificant impact on CO2 emissions. …"
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The role of protective genetic variants in modulating epigenetic aging
منشور في 2025"…In conclusion, APOE*E2 protective variants have a positive impact on epigenetic aging, while <i>PCSK9</i> protective variants have a significant effect on DNA methylation signatures. …"