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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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The Development And Significance Of Business Intelligence (BI) Platforms In Facilitating The Decision-Making Process In Dubai Government Entities
منشور في 2022"…Thus, the current study has focused on analysing the significance of BI platforms in improving the decision-making process in the Dubai Statistics Center (DSC), a governmental entity in Dubai. …"
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Functional GO-based membranes for water treatment and desalination: Fabrication methods, performance and advantages. A review
منشور في 2021"…<p dir="ltr">Graphene oxide (GO) and GO-based materials have gained a significant interest in the membrane synthesis and functionalization sector in the recent years. …"
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An image processing and genetic algorithm-based approach for the detection of melanoma in patients
منشور في 2018"…The first phase consists of an image processing-based method that extracts the Asymmetry, Border Irregularity, Color Variation and Diameter of a given mole. …"
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Methodological Approach to Assessing the Current State of Organizations for AI-Based Digital Transformation
منشور في 2024"…<p dir="ltr">In an era defined by technological disruption, the integration of artificial intelligence (AI) into business processes is both strategic and challenging. As AI continues to disrupt and reshape industries and revolutionize business processes, organizations must take proactive steps to assess their readiness and capabilities to effectively leverage AI technologies. …"
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A Novel Steganography Technique for Digital Images Using the Least Significant Bit Substitution Method
منشور في 2022"…Therefore, the proposed work, in this paper, is based on the Least Significant Bit (LSB) substitution method. …"
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Degree-Based Network Anonymization
منشور في 2020احصل على النص الكامل
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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