-
1
A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
-
2
-
3
-
4
Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
-
5
-
6
Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
-
7
The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
-
8
-
9
Treating Cancers Using Nature’s Medicine: Significance and Challenges
منشور في 2021"…In recent decades, the emphasis on identifying therapeutic plant-based active principles led to significant advancements in the identification and use of natural compounds to treat various diseases (Figure 1) [2,3]. …"
-
10
Dynamic Properties of Water Confined in Graphene-Based Membrane: A Classical Molecular Dynamics Simulation Study
منشور في 2019"…By decreasing the density of water molecules inside the membrane, we observed that water molecules form a droplet through a hydrogen bond with each other in the hydrophobic environment that stacked graphene sheets create. …"
-
11
-
12
Triboelectric multilayered electrospun co-polyamide-based wound dressings with inherent antibacterial properties
منشور في 2024"…This multilayered membrane embodies a promising strategy for promoting wound care consequences through its combination of biocompatibility, structural integrity, and inherent antibacterial properties. The potential impact of this research on the field of wound healing is significant and inspiring.…"
-
13
-
14
-
15
Effect of Strain Fields on Frequency Band Gaps of Periodic Lattice-Based Metamaterials
منشور في 2024"…Lattice-based metamaterials, known for their ability to deliver unique acoustic properties such as wave band gaps and direction-dependent phase velocities, are considered promising for noise filtering and acoustic sensor applications. …"
احصل على النص الكامل
article -
16
-
17
A review of extrusion-based additive manufacturing of multi-materials-based polymeric laminated structures
منشور في 2024"…A relatively nascent area of exploration within this realm is using Extrusion-based <u>Additive Manufacturing</u> (EbAM) to produce multi-materials-based laminated, clad, or panel-based <u>polymer composite</u> structures. …"
-
18
Biofunctional plant fibers and their bioactive-based materials: A critical review
منشور في 2025"…<p>Plants have been a significant source of natural fiber since antiquity. …"
-
19
-
20
Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"