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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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An Alternating Projection Framework for Elementwise Masked Nonlinear Matrix Decomposition
منشور في 2025احصل على النص الكامل
doctoralThesis -
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Ultrafiltration polyethersulfone-MXene mixed matrix membranes with enhanced air dehumidification and oil-water separation performance
منشور في 2024"…<p dir="ltr">This study demonstrates a novel method for enhancing ultrafiltration membrane performance by integrating Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene nanomaterials into a polyethersulfone (PES) matrix, creating mixed matrix membranes (MMMs). The structure and surface characteristics of the fabricated MMM containing different loadings of Mxene were thoroughly characterized using SEM, TEM, XRD, and AFM. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Mixed precision iterative refinement with adaptive precision sparse approximate inverse preconditioning
منشور في 2025"…Our numerical experiments show that this approach can potentially lead to a reduction in the cost of storing and applying sparse approximate inverse preconditioners, although a significant reduction in cost may comes at the expense of increasing the number of GMRES iterations required for convergence.…"
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Melt processing and properties of linear low density polyethylene-graphene nanoplatelet composites
منشور في 2016"…The electrical conductivity improved from 10−11 to 10−5 S/m at 150 rpm due to the high thermal stability of the GNPs and the formation of phonon and charge carrier networks in the polymer matrix. Higher extruder speeds result in a better distribution of the GNPs in the matrix and a significant increase in thermal stability and thermal conductivity. …"
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
منشور في 2017"…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …"
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Micropollutants Removal from Water using Microfiltration Membrane Modified with ZIF-8 Metal Organic Frameworks (MOFs)
منشور في 2016"…Compared to the unmodified membrane, incorporation of ZIF-8 onto the polymer matrix resulted in close to 40% increase in the membrane adsorption capacity and almost doubling its water permeability which could result in significant reduction in processing specific energy consumption. …"
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Strengthening of thin reinforced concrete slabs with CFRP laminates
منشور في 2016"…It was also observed that as the concrete strength increases, the gain in flexural capacity of RC slabs from CFRP reinforcement decreases. …"
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
منشور في 2017"…It is estimated that a 10% increase in the share of renewable energy could decrease CH4 emissions by about 0.26%. …"
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
منشور في 2020"…However, only in lower dose of sumac were significant decreases in the expression of oncogenic miR210 and increase of tumor-suppressive miR145 (miR21, miR22, and miR155 were not changed) observed. …"
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Recovery of business intelligence systems
منشور في 2018"…Denial of service affects the continuity of the healthcare system which in turn threatens patients’ lives, decreases the efficiency of the healthcare system and increases the operating costs of the attacked healthcare organization. …"
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