Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains حسب Riachi, Naji J.

"…We then attempted to correlate the differences among rat strains in their susceptibility to MPTP neurotoxicity in vivo with MPTP oxidation by monoamine oxidase (MAO) of the cerebral cortex, striatum, and brain microvessels in vitro. Despite the fact that the carotid route delivers much higher amounts of MPTP to the ipsilateral cerebrum than can be achieved by systemic injections, no significant dopamine depletion occured in ipsilateral striata of Sprague-Dawley rats (the most resistant strain), but significant reductions of about 40% in striatal dopamine were evident in the more sensitive strains. …"
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Preclinical impact of bevacizumab on brain and tumor distribution of irinotecan and temozolomide حسب Milane, Aline

"…Our results show that bevacizumab pre-treatment was associated with a reduced temozolomide brain distribution in tumor-free mice. In tumor bearing mice, bevacizumab increased temozolomide tumor distribution, although not statistically significant. …"
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Brain Connectivity Analysis Under Semantic Vigilance and Enhanced Mental States حسب Yahya, Fares

"…The results show that PDC is very sensitive to vigilance decrement and shows that the brain connectivity network is significantly reduced with increasing TOT, p < 0.05. …"
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Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor حسب Mahmoud A. Alomari (14780446)

"…Brain-derived neurotrophic factor (BDNF) is essential for neurocognitive function. …"

The outcome of severe traumatic brain injury in children in Qatar: Six-year study حسب Azhar Khattab (19774476)

"…Finally, the incidence of TBIs from road traffic crashes and injuries in Qatar are increasing significantly compared to other developing and developed countries. …"

Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae حسب Mungroo, Mohammad Ridwane

"…Moreover, these compounds were also conjugated with gold nanoparticles to further increase their amoebicidal activities. After conjugation with gold nanoparticles, amoebicidal activities of the drugs were increased by up to 56 and 37% against B. mandrillaris and N. fowleri, respectively. …"
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Qatar’s immigrants at higher risk of diabetes حسب Nature Research (16552612)

"…The results, however, suggest that Qatar’s immigrant population has a significantly increased risk of having undiagnosed T2D, and that glycated haemoglobin levels could be a useful diagnostic tool for early detection of the disease. …"

Assessment of Brain Function After 240 Days Confinement Using Functional Near Infrared Spectroscopy حسب Yahya, Fares

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Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain حسب Riachi, N.J.

"…However, 30 min after [3H]MPTP injection, brain retention of the 3H tracer was reduced significantly by pargyline treatment, and the ratio of brain MPTP/MPP+ was increased markedly.…"
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Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers حسب Yadav, Santosh K.

"…HIC showed decreased FA and increased MD in multiple brain sites as compared to both CHNM and HUC. …"
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Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population حسب Ghassibe-Sabbagh, Michella

"…People with T2DM showed a significant decrease in HDL-C levels. A strong correlation of overall hyperlipidemia with the diabetes affection status was shown (p < 0.0001). …"
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Western diet induces mild metabolic impairment and aggravates neuropathology in an experimental mouse model of traumatic brain injury حسب Judith, Nwaiwu

"…WD has been shown to impair cognitive function, decrease the brain's capacity to compensate for insult by affecting recovery as well as induce metabolic syndrome (MetS) which may be a risk factor for poor TBI prognosis. …"
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Biomolecular alterations in acute traumatic brain injury (TBI) using Fourier transform infrared (FTIR) imaging spectroscopy حسب Fazle Rakib (5768069)

"…Our results revealed that the total lipid and total protein content decreased significantly in the hippocampus, corpus callosum and thalamus after brain injury. …"

Dissecting the signaling pathways regulating the vascular endothelial growth factor (VEGF) in brain tumor cells. (c2017) حسب Nicolas, Samer Michel

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Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury حسب Sebnem Garip Ustaoglu (18460611)

"…Band area and intensity ratios, band frequency and bandwidth values of specific spectral bands showed that TBI causes significant structural and contextual global changes including decrease in carbonyl content, unsaturated lipid content, lipid acyl chain length, membrane lipid order, total protein content, lipid/protein ratio, besides increase in membrane fluidity with an altered protein secondary structure and metabolic activity in hippocampus 24 h after injury. …"

Initial risk assessment for pulmonary hypertension in patients with COPD حسب Yammine, Joe

"…Diffusion capacity was lower but did not reach statistical significance (P = 0.07). In multivariate analysis, statistically significant independent variables were >3% decrease in exercise oxyhemoglobin saturation and decline in prebronchodilator FEV1 (P = 0.01 and P = 0.04, respectively). …"
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The effect of Dopamine Agonists on patients with advanced Parkinson's disease subjected to subthalamic deep brain stimulation. (c2000) حسب Jabre, Mazen Gerges

"…Striatal dopamine concentration gets significantly reduced, and clinical symptoms, especially the motor handicap, prevail. …"
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When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial حسب Hourani, R.

"…Univariate analysis showed a significant increase in the frequency of epileptogenic lesions with decreasing age, the presence of developmental delay, and the number and types of seizures at presentation. …"
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A systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury حسب Muhammad Hamza Shuja (19748620)

"…<h3>Background </h3><p dir="ltr">Traumatic brain injury (TBI) poses significant health challenges, often leading to complications such as venous thromboembolism (VTE) and increased mortality rates. …"

Fourier Transform Infrared Imaging—A Novel Approach to Monitor Bio Molecular Changes in Subacute Mild Traumatic Brain Injury حسب Fazle Rakib (5768069)

"…Significant decrease in methyl content and a significant increase in olefinic content were observed in Co and CC regions of mTBI rat brain tissues. …"