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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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A decision support system for automating document retrieval and citation screening
منشور في 2021"…The proposed DSS is effective and can substantially decrease the document retrieval and citation screening steps' workload and error rate.…"
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Exploration and analysis of On-Surface and In-Air handwriting attributes to improve dysgraphia disorder diagnosis in children based on machine learning methods
منشور في 2023"…This work focuses on developing machine learning-based automated methods to build the dysgraphia screening tool for children. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Pharmacist input to depression screening and management in patients with diabetes: a systematic review
منشور في 2025"…All studies demonstrated the positive impact of pharmacists on depression screening, treatment initiation, and medication adherence., Some interventions failed to significantly improve clinical parameters such as HbA1c levels or depressive symptoms. …"
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High-throughput autoantibody screening identifies differentially abundant autoantibodies in autism spectrum disorder
منشور في 2023"…</p><h3>Materials and methods</h3><p dir="ltr">In this study, we screened serum samples from 93 cases with ASD and 28 healthy controls utilizing high-throughput KoRectly Expressed (KREX) i-Ome protein-array technology. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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A screening instrument for sleep apnea predicts airway maneuvers in patients undergoing advanced endoscopic procedures
منشور في 2010"…A previously validated screening tool for OSA (STOP-BANG) was used to identify patients at high risk for OSA (score, ≥3 of 8; SB+) or low risk (SB−). …"
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In silico virtual screening of lead compounds for major antigenic sites in respiratory syncytial virus fusion protein
منشور في 2022"…Using structure-based design and combination-based drug therapy, identified molecules could be modified to generate the next generation anti-RSV drugs.…"
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Exploration and analysis of On-Surface and In-Air handwriting attributes to improve dysgraphia disorder diagnosis in children based on machine learning methods
منشور في 2023"…This work focuses on developing machine learning-based automated methods to build the dysgraphia screening tool for children. …"
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When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial
منشور في 2021"…Univariate analysis showed a significant increase in the frequency of epileptogenic lesions with decreasing age, the presence of developmental delay, and the number and types of seizures at presentation. …"
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