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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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New susceptibility loci associated with type 2 diabetes. (c2011)
منشور في 2011احصل على النص الكامل
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masterThesis -
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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The Impact of Artificial Intelligence on Institutional Recruitment and Selection Processes
منشور في 2024"…The participants believed that most HR operations management in the future could depend on AI without human intervention. The research participants’ responses to using technology to enhance recruitment and selection processes were at a high level of significance (p ≤ 0.05). …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Anomalies Detection in Software by Conceptual Learning From Normal Executions
منشور في 2020"…Experimental results show that the generated patterns are significant in representing normal program executions. …"
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation
منشور في 2025"…In this study, we demonstrate that Prist effectively inhibits the proliferation of T-ALL cell lines (Jurkat and Molt 4) by inducing G0/G1 cell cycle arrest and triggering intrinsic and extrinsic caspase-dependent apoptosis. Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …"
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The apoptotic and anti‐proliferative effects of Neosetophomone B in T‐cell acute lymphoblastic leukaemia via PI3K/AKT/mTOR pathway inhibition
منشور في 2024"…This study investigates the effects of Neosetophomone B (NSP‐B), a meroterpenoid fungal metabolite, on T‐ALL cell lines, focusing on its anti‐cancer mechanisms and therapeutic potential. NSP‐B significantly inhibited the proliferation of T‐ALL cells by inducing G0/G1 cell cycle arrest and promoting caspase‐dependent apoptosis. …"
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Impacts of ultrasonication time and surfactants on stability and optical properties of CuO, Fe<sub>3</sub>O<sub>4</sub>, and CNTs/water nanofluids for spectrum selective applicatio...
منشور في 2022"…The study results revealed that surfactants have a significant effect on the stability of nanofluids over ultrasonication time. …"
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Genetic-Algorithm-Based Neural Network for Fault Detection and Diagnosis: Application to Grid-Connected Photovoltaic Systems
منشور في 2022"…<p dir="ltr">Modern photovoltaic (PV) systems have received significant attention regarding fault detection and diagnosis (FDD) for enhancing their operation by boosting their dependability, availability, and necessary safety. …"
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Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute...
منشور في 2023"…Due to its off-target toxicity, a more selective generation of PrAg/LF was re-engineered by making its activation dependent on cleavage by tumor specific cell surface proteases enriched on the surface of tumor cells and not normal cells. …"
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masterThesis