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The Detection of Dysarthria Severity Levels Using AI Models: A Review
منشور في 2024"…This systematic review aims to comprehensively analyze current methodologies for classifying dysarthria based on severity levels, highlighting effective features for automatic classification and optimal AI techniques. …"
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Detection of statistically significant network changes in complex biological networks
منشور في 2017"…In addition, its application highlights several novel candidates that cannot be detected by standard single network-based approaches.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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COVID-19 biomarkers for severity mapped to polycystic ovary syndrome
منشور في 2020"…<p dir="ltr">Large scale multi-omics analysis has identified significant differences in the biomarkers between COVID-19 disease and control subjects [1]. …"
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Evaluation of the effects of standardization process of severe trauma treatment in China
منشور في 2015"…</p><h3 dir="ltr">Conclusion</h3><p dir="ltr">Staff training and standardization processes can significantly improve the treatment efficiency of severe trauma based on current personnel and organizations of severe trauma treatments in China.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone
منشور في 2022"…</p><p><br></p><h3>Results: </h3><p dir="ltr">We identified 100 CpG methylation sites significantly associated with PDB severity at FDR <0.05. …"
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Endoscopic removal of the wireless pH monitoring capsule in patients with severe discomfort
منشور في 2006"…Background Few patients have significant symptoms during wireless esophageal pH monitoring, and the capsule typically sloughs spontaneously. …"
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The outcome of severe traumatic brain injury in children in Qatar: Six-year study
منشور في 2015"…The Glasgow Coma Scale (GCS) was used to assess severity of TBIs. This study was based on 65 children suffering from severe traumatic brain injury, of which 12 of them died within the first month of admission in pediatric intensive care unit. …"
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Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene
منشور في 2004"…The GG genotype was also significantly higher among patients (12.6%) than in controls (4.2%). χ2 analysis and family-based association studies were performed and suggested the association of CTLA4 exon 1 G polymorphism with T1D (p = 0.0229). …"
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Depression, anxiety and obsessive–compulsive symptoms in relation to nutritional status and outcome in severe anorexia nervosa
منشور في 2012"…There is clinical consensus that depressive symptoms and anxiety may in part be sequelae of malnutrition in AN. However, evidence-based data are still very rare. The present study among severe AN patients investigates links between these psychological variants and nutritional status at admission and subsequent to nutritional rehabilitation. …"
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