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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Evaluating the impact of the COVID-19 pandemic on the geospatial distribution of buildings' carbon footprints associated with electricity consumption
منشور في 2024"…The carbon footprint (CF) linked to electricity consumption in buildings has become a significant environmental issue because of its significant role in greenhouse gas emissions. …"
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A hybrid 3D CNN-LSTM model with soft spatial attention mechanism for accurate hyperspectral image classification
منشور في 2025"…The model utilizes 3D CNNs for the extraction of joint spatial-spectral features, employs LSTMs to capture sequential dependencies across spectral bands, and incorporates soft spatial attention mechanism to emphasize discriminative spatial regions. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Accessibility of green spaces in a metropolitan network using space syntax to objectively evaluate the spatial locations of parks and promenades in Doha, State of Qatar
منشور في 2021"…The research shows there is spatial and social logic to the physical and spatial characteristics of open green spaces in Doha above a certain size. …"
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Evaluating the impact of the COVID-19 pandemic on the geospatial distribution of buildings' carbon footprints associated with electricity consumption
منشور في 2024"…<p>The carbon footprint (CF) linked to electricity consumption in buildings has become a significant environmental issue because of its significant role in greenhouse gas emissions. …"
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Unveiling the Nexus Between Land Use, Land Surface Temperature, and Carbon Footprint: A Multi-Scale Analysis of Building Energy Consumption in Arid Urban Areas
منشور في 2024"…<p dir="ltr">Urbanization and land use changes, especially in arid environments, significantly impact local climate and energy demand. …"
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
منشور في 2002"…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …"
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
منشور في 2015"…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …"
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