Intratumoral FoxP3⁺Helios⁺ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer حسب Azharuddin Sajid Syed Khaja (19720114)

"…Levels of CD4⁺FoxP3⁺Helios⁺ Tregs were significantly increased in the TME. …"

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors حسب Noura Aldous (15429873)

"…</p><h3>Conclusions/interpretation</h3><p dir="ltr">These findings suggest that pancreatic hypoplasia and reduced islet cell formation associated with RFX6 mutations are not due to alterations in PDX1⁺/NKX6.1⁺ PPs but instead result from cellular apoptosis and downregulation of pancreatic endocrine genes.…"

FoxP3⁺ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets حسب Reem Saleh (3513056)

"…We discuss the prognostic significance of FoxP3⁺ Tregs in different cancers and their potential use as prognostic biomarkers. …"

National Ambulance Service’s Preparation for the FIFA World Cup Qatar 2022^TM حسب Montaha Khaled Chakif (18505072)

Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications حسب Fang Yu (156838)

"…</p> <h2>Key points</h2> <ul> <li>A floxed stromal interaction molecule 1 (STIM1) hypomorph mouse model was generated with significant reduction in Ca²⁺ influx through store-operated Ca²⁺ entry (SOCE), resulting in defective nuclear translocation of nuclear factor of activated T cells, cytokine production and inflammatory response. …"

Airway surface liquid volume expansion induces rapid changes in amiloride-sensitive Na⁺transport across upper airway epithelium-Implications concerning the resolution of... حسب Fouad Azizi (11835843)

"…We previously demonstrated that elevation of submucosal hydrostatic pressure increases airway epithelium permeability resulting in ASLV expansion by 500 μL cm⁻² h⁻¹. …"

Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients حسب Salman M. Toor (8854751)

"…Interestingly, the expansion of peripheral GMCs correlated with higher stage and histological grade of cancer, thereby suggesting their role in cancer progression. Furthermore, an increase in CD33⁺CD11b⁺HLA-DR⁻CD14⁻CD15⁻ immature myeloid cells was also observed in CRC tumor tissue. …"

Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation حسب Mahéva Vallet (18456729)

"…At 52 weeks, Oc.S/BS did not differ between genotypes but single labelled perimeter (SL.Pm/B.Pm (%)) was significantly higher in Rin3⁻/⁻ mice (24.4 ± 6.4 vs. 16.5 ± 3.8, p = 0.003). …"

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... حسب Masri, Oussama Samer

"…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Cardiorespiratory Fitness and Performance Adaptations to High-Intensity Interval Training: Are There Differences Between Men and Women? A Systematic Review with Meta-Analyses حسب Merilyn Lock (9440240)

"…Significant heterogeneity was present for both V̇ O_2max and PPO (I², range: 62.06–78.80%). …"

The Immunophenotyping Changes of Peripheral CD4+ T Lymphocytes and Inflammatory Markers of Class III Obesity Subjects After Laparoscopic Gastric Sleeve Surgery – A Follow-Up Study... حسب Nasser M Rizk (18810328)

"…LGS caused a significant reduction in BMI by 32%, p< 0.0001. LGS intervention significantly decreased CD4+ T-lymphocytes and effector memory (TEM) cells but increased T-regulatory (Treg), naïve, and central memory (TCM) cells, with all p values < 0.05. …"

Deep learning-based modeling of land use/land cover changes impact on land surface temperature in Greater Amman Municipality, Jordan (1980–2030) حسب Khaled F. Alkaraki (22051967)

"…The results of modeling LST showed an increase in average LST for all land cover types, with the most significant increases evident within urban areas and Rangelands/Sparsely vegetated areas. …"

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients حسب Salman M. Toor (8854751)

"…We found a significant increase in the levels of CD4⁺FoxP3⁺Helios⁺ T cells, which represent potentially highly immunosuppressive Tregs, in the CRC TME. …"

Hyper-Hypo study: A Retrospective Observational Study of Neonatal Hypoglycemia Related to Maternal Hypertension حسب Thiruveni Ramkumar (17075051)

"…On the other hand, neonates of hypertensive mothers administered with methyldopa showed a significant decrease of initial blood glucose reading.…"

Enhanced natural convection in a U-shaped baffled cavity: Synergistic effects of magnetic fields and wall oscillations on Nano-encapsulated PCM حسب Ahmed M. Hassan (8893106)

"…Results show that the Rayleigh number has the most significant impact, increasing the time-averaged Nusselt number by 129.8 % as <i>Ra</i> rises from 10³ to 10⁵. …"

Self-reported awareness and attitude of cancer patients towards clinical nurse coordinators حسب Deeb, Ahmad

"…Responses on Likert scales were converted to percentage mean scores. Results: The overall percentage mean scores ± standard deviation of knowledge was 59 ± 17, perception towards clinical nurse coordinators (79 ± 14) and attitude towards seeking their services (69 ± 16). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Sleeve Gastrectomy in Patients with Type 2 Diabetes: Anthropometric and Cardiometabolic Improvements at 1, 3, 5, 7, and 9 years—Are the Initial Benefits Sustained? حسب Wahiba Elhag (5245547)

"…Mean HbA1c significantly decreased from 8.1%preop to 6.77%_{year 9}. …"

Walking around the preferred speed: examination of metabolic, perceptual, spatiotemporal and stability parameters حسب Lina Majed (7485380)

"…While metabolic, perceptual and spatiotemporal values were sensitive to the smallest change in speed (i.e., 0.5 km·h⁻¹⁾, a significant increase in the rate of carbohydrate oxidation and decrease in % fat oxidation were only observed at speeds above PWS. …"

Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy حسب Remy Thomas (702843)

"…More specifically, we found an increase in IFN-γ secretion by CD8 + T cells and cancer-cell-killing of HLA-A*0201/LDHC positive breast cancer cells by LDHC⁴¹⁻⁵⁵- and LDHC^288−303-induced T cells, albeit with a possible antigen recognition threshold. …"

Effect of clinical hyperthyroidism and hypothyroidism on patent diabetes. 59 cases حسب Hirbli, K.

"…Following treatment of the hyperthyroidism, control was improved in 63%, with an 11-83% (mean 44%) decrease in insulin dosage in 59% of them. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل