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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Oral contraceptive pills and possible adverse effects
منشور في 2014"…Since their introduction to the market, there have been significant changes in the drug content and formulations of these products, in part to decrease the risk of adverse effects. …"
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
منشور في 2010"…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …"
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The Impact of Transformational Verses Strategic Leadership Styles in the Success of Engineering Teams
منشور في 2023"…Engineering teams' success is based on their ability to work effectively and use their skills, experience, and knowledge to achieve results. …"
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Culture Diversity Impacts on Teams Performance and Innovation Role in Dubai Private Sector
منشور في 2012"…Cultural diversity is having a significant impact on organizations at the current time. …"
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Innovation by Mergers and Acquisitions: Paradox of Acquired Organization’s Leadership Teams Commitment to Internal Innovation
منشور في 2013"…This dissertation highlights the trade off between growth via M&A and executive leadership team commitment to internal innovation (R&D). It is based on the results gathered from the employees of organizations XYZ and ABC which has combined to form a resultant entity DRC, part of a conglomerate called AIMI. …"
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The Influence of Kanban Project Management Methodology Success Factors on Data Science Project Teams
منشور في 2022"…The results of the study were based on the collection of survey data from the target population of project managers and other members of the Data Science project teams. …"
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The Impact of School Senior Leadership Team (SLT) Emotional Intelligence on Teachers’ Professional Development Programs and School Performance in the UAE
منشور في 2020"…Results revealed that school leadership team emotional intelligence has a significant effect on teachers’ professional development; this is true for the interpersonal relationship (β = .367, p < 0.01), and the ability of school leadership team to adapt to situations based on existing demands (β = .224, p < 0.01). …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Emotional Intelligence in Leaders: A Case study of its effect on Team performance in the construction industry of Dubai, U.A.E
منشور في 2009"…The purpose of this study is to qualitatively examine the relationship between emotional intelligence of leaders on team performance, based on the Emotional Intelligence Inventory test (ECI) of Hay Group. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"