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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Grid Iron Patterns & Detached Villas as the Main Drivers of Sharjah City’s Urban Sprawl
منشور في 2021"…On the demographic side, the massive external population migration that trickled towards the city resulted in a major defect in its demographic structure, which represented a decrease in the percentage of the citizen population to only about 10% of the non-citizen population. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Preoperative Bevacizumab Does Not Significantly Increase Postoperative Complication Rates in Patients Undergoing Hepatic Surgery for Colorectal Cancer Liver Metastases
منشور في 2008"…No significant associations were identified between BV use and timing of BV discontinuation and postoperative complications. …"
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Examining time-to-transport decisions in Emergency Medical Services
منشور في 2024"…</p><h3>Results</h3><p dir="ltr">Figure 1 indicates the transport probabilities as inferred from the Cox regression. As the time spent on scene increases (due to various reasons, among them: spending more time providing clinical treatment and health education because the patient decided not to go to the hospital, or the crew spending more time convincing the patient to go to the hospital by explaining the potential complications of their condition and the potential outcomes of a refusal to go to hospital), the probability of transporting the patient decreases. …"
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Coping mechanisms among Lebanese first-time college students
منشور في 2012"…Implications for Nursing Practice and Research: The results of this study will provide a better understanding of factors that are predictive of decreased well-being in Lebanese first-time college students and will be valuable in developing culturally sensitive intervention of stress and coping management program with a surveillance system and a systematic planning and evaluation procedure to respond to emerging and changing students’ needs at the Lebanese American University.…"
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Modelling the Impact of Bottlenecks on Arterial Travel Time Using Neural Networks
منشور في 2012احصل على النص الكامل
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Ensemble-Guard IoT: A Lightweight Ensemble Model for Real-Time Attack Detection on Imbalanced Dataset
منشور في 2024"…Ensemble learning by combining multiple machine learning models offers a significant advantage in reducing computational costs compared to deep learning models, making it a practical solution for real-time applications. …"
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Bank-Specific and Macroeconomic Determinants of Islamic Banks Profitability: The Case of GCC Countries
منشور في 2020"…The bank’s profitability is measured by the return on asset (ROA), whereas the independent variables that tested are capital adequacy ratio, operational efficiency, assets quality, financial leverage, bank size, liquidity risk, GDP growth, and inflation rate. The regression results indicate that bank-specific determinants including capital adequacy ratio, financial leverage, and operational efficiency are statistically significant and have negative relationship with the Islamic bank’s profitability. …"
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