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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Validation of the Arabic version of the Social Communication Questionnaire
منشور في 2019"…Scores on the three Social Communication Questionnaire subscales also differed significantly between the groups ( p < 0.001). Of the 39 items, 37 were endorsed significantly more often in the autism spectrum disorder group. …"
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Effect of corporate ethics and social responsibility on OCB: the role of employee identification and perceived CSR significance
منشور في 2021"…Partial least square structural equation modeling (PLS-SEM) is used to analyze the data and multi-group analysis is conducted to investigate the role of perceived CSR significance. …"
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The Impact of Cooperative Learning on Speaking Performance among University Foundation Programme Students
منشور في 2019"…Data were analyzed using the mean scores, standard deviation and paired sample t test. A significant difference was noticed on the students’ speaking performance after being exposed to CL instruction in comparison to the students in the control group. …"
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Arabic Translation and Validation of the Adult Oral Health Standard Set Questionnaire
منشور في 2025"…Cronbach’s alpha coefficient was 0.75, indicating satisfactory internal consistency. For construct validity, Spearman’s rho correlation coefficient ranged from 0.14 to 0.90, indicating a statistically significant correlation with the WHO questionnaire. …"
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Development and Validation of the Motivation for Tutoring Questionnaire in Problem-Based Learning Programs
منشور في 2017"…PurposeThere are no published instruments, which measure tutor motivation for conducting small group tutorials in problem-based learning programs. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Development and validation of a multi-dimensional COVID-19 vaccine hesitancy questionnaire
منشور في 2023"…Phase 1 entailed a qualitative approach to developing the questionnaire, including a literature search, expert panel review, and focus group discussion. Phase 2 used a quantitative method for establishing the content and construct validity of the questionnaire via exploratory and confirmatory factor analysis (EFA & CFA). …"
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Optimal Group Formation in Dense Wi-Fi Direct Networks for Content Distribution
منشور في 2019"…The results reveal significant performance gains in terms of group formation time and network throughput. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Validating a Structural Model of Destination Image, Satisfaction, and Loyalty Across Gender and Age
منشور في 2015"…We confirm that DI predicts satisfaction and has a significant direct and indirect effect on loyalty. After examining the validated structural model across different groups of respondents based on gender, age, and the gender by age interaction, we found that the model constructs differ across some of the groups. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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