A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

"…Further, analysis of trajectories for <u>hydrogen bonds</u> (H-bonds) formed between NLuc and furimazine revealed substantial H-bond interaction between R162 and Q32 residues. Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …"

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. By elucidating a mechanistic basis for the increased affinity of the N501Y mutant S1-RBD for ACE2, we believe that the results presented here will aid in developing therapeutic strategies against SARS-CoV-2 including designing of therapeutic agents targeting the ACE2-S1-RBD interaction.…"

Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation حسب Feng, Samuel

"…Sympathovagal balance was assessed in 124 healthy participants through heart rate variability (HRV) analysis and compared across changes in HN concentrations divided into quintiles, with values of HN ranging from 64.6 to 343.2 pg/mL. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"

The Effect of the Variation of the Modulus of Subgrade Reaction on the Design of Large Shallow Foundations حسب Al Kaaby Al Zoaby, Hassan

"…With the use of variable coefficient across the mat foundation, a significant decrease in the steel reinforcement is witnessed and an optimized/ more adapted steel distribution is observed.…"
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Social Media Use and Body Checking Among Lebanese Adults حسب Korkomaz, Aya

"…However, self-esteem, gender, and the number of online friends and their interaction with them lost significance. Additionally, the most significant variable in explaining the variation in body checking was emotional eating. …"
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Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults حسب Khaddaj, Rashel

"…Furthermore, the change between both groups was significantly different (-7.61 ±4.03 in the Vitamin D group, -3.50±1.54 in the control group; p=<0.001) Conclusion: The present study shows thata 50.000 IU/week dose of vitamin D supplementation for 3 months was enough to increase vitamin D levels beyond sufficient and decrease depression symptoms in Saudi Arabian Adults. …"
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Why do some countries produce more capital intensive output than others? حسب Toukan, Amjad

"…In my game theoretic analysis I model the interaction between firms and corrupt government officials as a contest while allowing for international variability in the quality of governance. …"
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines حسب Ismail, Jana

"…The combination of CBD with either cisplatin or paclitaxel exhibited a significant antagonistic interaction against SK-OV-3 cell line when compared to individual treatment (CI > 1). …"
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Prediction of critical total drawdown in sand production from gas wells: Machine learning approach حسب Fahd Saeed Alakbari (10701871)

"…The effects of all independent variables on the CTD are displayed in three-dimensional plots and showed significant interactions.…"

Disrupted harvests: how Ukraine – Russia war influences global food systems – a systematic review حسب Hamid El Bilali (15864930)

"…This systematic study delves into this intricate interaction, examining scholarly literature to determine the magnitude and complexities of the war’s impact on global agri-food systems. …"

Antecedents and consequences on employee turnover intention in the hospitality industry in Lebanon حسب Baajour, Maya

"…H1 (There is an indirect relationship between PAT and Turnover) showed a significant result that when training is available employees’ intention to leave decreases. …"
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Walking around the preferred speed: examination of metabolic, perceptual, spatiotemporal and stability parameters حسب Lina Majed (7485380)

"…Results indicated a significant main effect of speed on all studied variables. …"

Coping mechanisms among Lebanese first-time college students حسب Doumit, Rita

"…Stress (r= -.547, p < .01) had the highest correlation with well-being followed by social support (r= .377, p < .01), resilience (r = .366, p < .01), uncertainty (r= -.353, p < .01), withdrawal coping (r = -.243, p < .01), and gender (p < .01) as a controlling variable. When all those factors were combined together, six variables in addition to gender accounted for significant increments of variance in the level of wellbeing. …"
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Release of colloids in saturated porous media under transient hydro-chemical conditions: A pore-scale study حسب Safna Nishad (16932474)

"…<p dir="ltr">The deposition and consequent release of colloids pose a significant challenge to the environment, groundwater quality and human health. …"

DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation حسب Abdelilah Arredouani (10914455)

"…In co-immunoprecipitation assays, DNAJB3 interacts with both JNK1 and IKKβ kinases. However, the functional impact of such interaction on their activities has not been investigated. …"

Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank حسب Al-Hamdani, Mohammed

"…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R2 = 0.065, ΔF(7, 1724) = 3.34, p = 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …"
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Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice حسب Zeeni, N.

"…When comparing diet effects, while the HF diet did not induce any change in activity, reductions in MEMRI-associated signal were found in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) when comparing the HP to the HC diet. In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. …"
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Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort حسب Fatima Qafoud (14778571)

"…Elevated QTc was observed in CAD patients, whereas decreased QTc was correlated with decreased levels of calcium and potassium. …"

Nutritional Status and Clinical Outcomes of Children with Medical Complexity in the United Arab Emirates: A Retrospective Cross-Sectional Study حسب Al Slaybe, Maryam

"…Preterm birth was significantly associated with lower WAZ (β = -0.849, p < 0.001) and LAZ (β = -1.464, p < 0.001) scores. …"
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