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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Staff Development: A Study Into The Significance of Staff Professional Development Programs for Educators and Students Achievement
منشور في 2011"…Literature review conducted puts forth the rationale for such research work. In this context, various models of staff development have been discussed along with pros and cons. …"
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Effect of corporate ethics and social responsibility on OCB: the role of employee identification and perceived CSR significance
منشور في 2021"…Partial least square structural equation modeling (PLS-SEM) is used to analyze the data and multi-group analysis is conducted to investigate the role of perceived CSR significance. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Numerical Evaluation of Shear Strength Enhancement in RC Beams Incorporating Various Web Opening Configurations and Pre-Stressed Fe-SMA Bar Sizes
منشور في 2024"…This study presents a numerical investigation to enhance the shear strength of RC beams with various web opening shapes by integrating pre-stressed Fe-SMA (Iron-based Shape Memory Alloy) bars. …"
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The effectiveness of physical models in teaching anatomy
منشور في 2016"…The meta-analytical results are: educational methods using physical models yielded significantly better results when compared to all other educational methods for the overall knowledge outcome (p < 0.001) and for spatial knowledge acquisition (p < 0.001). …"
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The Impact of Implementing Maturity Models on IT Project Performance
منشور في 2021"…This research found that the implementation of maturity models have a significant relationship with the performance of IT projects, and plays an important role in influencing. …"
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INTEGRATING TRADITIONAL AND UNCONVENTIONAL CSR THEORIES AND MODELS – A THEORETICAL
منشور في 2020"…The paper makes a significant contribution to CSR research by offering an inclusive read on the theoretical underpinnings as well as models developed by academicians and Internationally recognised organisations at one glance, thus enabling organisations to first choose an appropriate theoretical stance which is in lines with their organisational policy and later employ corresponding models which aligns both with the theory and organisational structure.…"
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The Business Models of Frugal Enterprises for Sustainable Development in a Constrained Environment
منشور في 2024"…Drawing on institutional theory perspective and the resource-based view, this article explores how frugal enterprises create business models for serving overlooked customers in emerging markets and overcoming the various constraints and institutional voids. …"
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Scaffold‑based 3D cell culture models in cancer research
منشور في 2024"…These models bridge traditional 2D cell cultures and animal models, offering a cost-effective, scalable, and ethical alternative for preclinical research. …"
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Across the Spectrum In-Depth Review AI-Based Models for Phishing Detection
منشور في 2024"…This study conducts a comparative analysis of more than 130 articles published between 2020 and 2024, identifying challenges and gaps in the literature and comparing the findings of various authors. The novelty of this research lies in providing a roadmap for researchers, practitioners, and cybersecurity experts to navigate the landscape of machine learning (ML) and deep learning (DL) models for phishing detection. …"