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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Rayyan—a web and mobile app for systematic reviews
منشور في 2016"…The “suggestions” and “hints,” based on the “prediction model,” appeared as testing progressed beyond five included studies. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Novel interpretable and robust web-based AI platform for phishing email detection
منشور في 2024"…This research offers a practical and highly accurate solution, contributing to the fight against phishing by empowering users with a real-time web-based application for phishing email detection.…"
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An Ontology-based Semantic Web for Arabic Question Answering: The Case of E-Government Services
منشور في 2018"…These results confirm that the semantics-based approach significantly outperforms the keyword-based approach.…"
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Reliability of online pregnancy-related information and associated feelings of worry among expectant women in Qatar
منشور في 2022"…Thus, antenatal care providers should guide expectant women on how to access high-quality web-based information.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Pregnancy and Childbirth<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12884-022-04457-w" target="_blank">https://dx.doi.org/10.1186/s12884-022-04457-w</a></p>…"
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Metaheuristic algorithm for testing web 2.0 applications. (c2012)
منشور في 2012احصل على النص الكامل
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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article