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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Distribution network line protection in the presence of distributed generation
منشور في 2015"…When calculating the fault current levels in the network to choose the protection relay settings, it is important to correctly account for the fault contributions of inverter based DGs that represent a significant proportion of DGs connected to the distribution network. …"
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masterThesis -
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Feeder protection challenges with high penetration of inverter based distributed generation
منشور في 2013"…The increasing proportion of inverter based distributed generation (DG) in the power system may limit the short circuit power available at distribution substations and consequently cause significant troubles for the protection of distribution feeders where DG are connected. …"
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conferenceObject -
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Hierarchical multi-head attention LSTM for polyphonic symbolic melody generation
منشور في 2024"…Qualitative analysis conducted on the generated melodies shows significantly improved loss scores on MSE over baseline methods, and is able to generate melodies that were both musically coherent and expressive. …"
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Resource allocation and reallocation techniques in high-level synthesis with testability constraint
منشور في 1994"…Thus, the design is testable by construction and there is no need for the traditional post-design test insertion methods. The most significant aspect of this work is that it covers the void between the fields of high-level synthesis and design for testability. …"
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masterThesis -
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Bit-level pipelined digit serial GF(2m) multiplier
منشور في 2001"…Furthermore, the latency of the new multiplier is significantly less than the latency of the existing bit-level pipelined digit-serial multiplier…"
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RFX3 is essential for the generation of functional human pancreatic islets from stem cells
منشور في 2025"…The loss of <i>RFX3</i> disrupted pancreatic endocrine gene regulation, reduced the number of hormone-secreting islet cells and impaired beta cell function and insulin secretion. Despite a significant reduction in the expression levels of pancreatic islet hormones, the pan-endocrine marker chromogranin A remained unchanged at both EP and islet stages, likely due to an increase in the abundance of enterochromaffin cells (ECs). …"
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Design analysis and experimental validation of a multi‐level inverter for vehicle to home application
منشور في 2023"…A reduced number of switches with a single DC source (EV battery) is used to generate the 11‐level of output voltage and current waveform. …"
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An overview of future sustainable nuclear power reactors
منشور في 2013"…In particular, the nuclear technology is described and the classification of the current and future nuclear reactors according to their generation is provided. The analysis has shown that generation II reactors currently in operation all around the world lack significantly in safety precautions and are prone to loss of coolant accident (LOCA). …"
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article