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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The impact of socio-economic factors on waste generation in the UAE
منشور في 2024احصل على النص الكامل
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Detection of statistically significant network changes in complex biological networks
منشور في 2017"…</p><h3>Methods</h3><p dir="ltr">In this paper, we propose an improvement over the state-of-the-art based on the Generalized Hamming Distance adopted for evaluating the topological difference between two networks and estimating its statistical significance. The proposed procedure exploits a more effective model selection criteria to generate <i>p</i>-values for statistical significance and is more efficient in terms of computational time and prediction accuracy than literature methods. …"
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Advancing Interpretability in Sequential Models Through Generative AI Rationalization Using GPT-4
منشور في 2025"…Our study introduces a hybrid model that integrates traditional sequential prediction models with GPT-4, aiming to generate detailed, context-sensitive explanations for model outputs. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Preterm birth in low-middle income Countries
منشور في 2024"…Preterm birth (PTB), remains a major cause of significant morbidity and mortality world-wide with about 12–15million preterm births occurring every year. …"
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Examining the Use of Generative Artificial Intelligence in Higher Education and Its Impact on Social Sustainability: An Integrated Model of UTAUT2 and T-EESST
منشور في 2024"…The aim of this research entails the proposing and advancing of a model that enhances the adoption of GenAI in an educational setting that is based on Technology-Environmental, Economic, and Social Sustainability Theory (T-EESST) and the extended Unified Theory of Acceptance and Use of Technology (UTAUT2) model. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
منشور في 2025"…The computational results demonstrate the superiority of the proposed models through a comparative analysis against state-of-the-art approaches across fifteen significant wave height time series, validated by three error metrics and a statistical test.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Small-Signal Stability Analysis and Parameters Optimization of Virtual Synchronous Generator for Low-Inertia Power System
منشور في 2025"…This paper presents a comprehensive small-signal modeling and stability analysis framework for grid-connected virtual synchronous generators (VSGs), integrating: an LCL-filter interfaced power converter, active/reactive power loop (APL/RPL) controllers, and dual-loop PI-based current and voltage control. …"
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Mixed precision iterative refinement with adaptive precision sparse approximate inverse preconditioning
منشور في 2025"…<p dir="ltr">Hardware trends have motivated the development of mixed precision algorithms in numerical linear algebra, which aim to decrease runtime while maintaining acceptable accuracy. …"