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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis
منشور في 2025"…In conclusion, standalone phacoemulsification significantly lowers IOP and reduces the need for glaucoma medications in patients with glaucoma.…"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway
منشور في 2022"…Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. …"
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“Determinants of Body Image Dissatisfaction among an LGBTQ community in Lebanon”
منشور في 2021"…To date, a priori studies revealed inconsistent results with regards to body image dissatisfaction among sexual minorities. …"
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Classification and segmentation of kidney MRI images for chronic kidney disease detection
منشور في 2024"…Utilizing the Zenodo dataset comprising 1299 kidney MRI images from 100 T2-weighted abdomen MRI scans, our investigation reveals that Vision Transformers (ViT) based model EfficientNet_b1 exhibited superior performance compared to other models. …"
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Toward Adaptive Intrusion Detection Systems for UAVs Using Cyber-Physical Image Analysis
منشور في 2025"…<p dir="ltr">The rapid proliferation of uncrewed aerial vehicles (UAVs) across modern applications has significantly heightened their susceptibility to cyber and physical security threats. …"
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Self-Supervised Learning Powered by Synthetic Data From Diffusion Models: Application to X-Ray Images
منشور في 2025"…These findings underscore a significant advancement in the generation of synthetic medical images, providing a viable approach to creating realistic, biomarker-preserving datasets that ensure patient confidentiality and enable diverse applications in medical imaging.…"
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Biomolecular alterations in acute traumatic brain injury (TBI) using Fourier transform infrared (FTIR) imaging spectroscopy
منشور في 2021"…Our results revealed that the total lipid and total protein content decreased significantly in the hippocampus, corpus callosum and thalamus after brain injury. …"
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Deep Learning-Based Classification of Chest Diseases Using X-rays, CT Scans, and Cough Sound Images
منشور في 2023"…The scalogram method is used to convert the cough sounds into an image. Before training the proposed DCDD_Net model, the borderline (BL) SMOTE is applied to balance the CXR, CT scans, and cough sound images of nine chest diseases. …"