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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis
منشور في 2025"…In conclusion, standalone phacoemulsification significantly lowers IOP and reduces the need for glaucoma medications in patients with glaucoma.…"
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A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation
منشور في 2009"…Polymorphisms leading to an amino acid change were further investigated for changes in global DNA methylation by differential methylation hybridization. This analysis revealed that a rare change at DNMT3L (R271Q) was associated with significant DNA hypomethylation. …"
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Developing a Stochastic Model to Predict Cost Overrun due to the Causes of Projects Delay in Oil Fields Construction Industry
منشور في 2020"…In addition, the author used regression analysis and Monte Carlo simulation to develop a stochastic model to map the causes of projects delay to cost overrun. The research results revealed that poor contractor works was found to have the most significant positive impact in the delay experienced by the projects considered in this work. …"
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A GHRHR founder mutation causes isolated growth hormone deficiency type IV in a consanguineous Pakistani family
منشور في 2023"…</p><h3>Results</h3><p dir="ltr">All affected individuals presented with a short stature without gross skeletal anomalies and significantly reduced serum GH levels. Genetic mapping revealed a homozygous nonsense mutation [NM_000823:c.G214T:p.…"
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MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM
منشور في 2020"…Interestingly, interrogation of the expression levels of hsa-miR-205 and hsa-miR-214 in the METABRIC breast cancer dataset revealed significantly poor overall survival in patients with downregulated expression of miR-205 [HR = 0.75 (0.61–0.91)], p = 0.003 and hsa-miR-214 [HR = 0.74 (0.59–0.93) p = 0.008]. …"
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Invasive Milk Thistle (Silybum marianum (L.) Gaertn.) Causes Habitat Homogenization and Affects the Spatial Distribution of Vegetation in the Semi-Arid Regions of Northern Pakistan
منشور في 2022"…The community composition significantly changes with changes in invasion intensity. …"
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Altered regulation of cell migration in IRF6-mutated orofacial cleft patients-derived primary cells reveals a novel role of RhoGTPases in cleft/lip palate development
منشور في 2021"…In order to unravel the causes leading to the occurrence of the cleft, both genetics and molecular factors are being studied. …"
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masterThesis -
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Arsenic contamination in rice: a DPSIR analysis with a focus on top rice producers
منشور في 2025"…<p>Arsenic contamination in rice poses significant risks to public health and food security. …"
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
منشور في 2017"…After controlling for other sources of emissions, U.S. states that produce a larger share of renewable energy are found to have lower GHG emissions. …"
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
منشور في 2017"…Flow cytometry analysis revealed that treatment with 10 μg/ml HC significantly increased the number of cells undergoing late apoptosis (28%), while 25 μg/ml caused a larger cell shift towards late apoptosis (46.6%) and necrosis (39%). …"
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Why do some countries produce more capital intensive output than others?
منشور في 2016"…Based on my model I offer an explanation for the variation in physical capital intensity across countries where the model predictions show that a lower quality of governance in a country results in a decrease in the output of capital-intensive goods and an increase in the output of labor-intensive goods. …"
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Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults
منشور في 2022"…Furthermore, the change between both groups was significantly different (-7.61 ±4.03 in the Vitamin D group, -3.50±1.54 in the control group; p=<0.001) Conclusion: The present study shows thata 50.000 IU/week dose of vitamin D supplementation for 3 months was enough to increase vitamin D levels beyond sufficient and decrease depression symptoms in Saudi Arabian Adults. …"
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masterThesis