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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
منشور في 2008"…Treatment via o.g. demonstrated minimal toxicity and detailed histological examination of the spleen, kidney, lung, heart, and brain by a pathologist blinded to the treatment group failed to reveal any significant abnormalities in mice treated with WP1066. …"
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Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis
منشور في 2025"…In conclusion, standalone phacoemulsification significantly lowers IOP and reduces the need for glaucoma medications in patients with glaucoma.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Machine Learning in the Analysis of Social Problems: The Case of Global Human Trafficking
منشور في 2019"…The exploration of the dataset revealed 61% of missing data — another incentive for the applicability of machine learning via multiple imputation using chained equations (MICE) instead of single imputation or deletion. …"
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
منشور في 2024"…Herein, we evaluated the in vivo effects of chronic administration of AB-FUBINACA on the <u>hippocampus</u> in mice. Our results revealed that the administration of AB-FUBINACA induced a significant impairment in recognition memory associated with histopathological changes in the hippocampus. …"
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
منشور في 2024"…Herein, we evaluated the in vivo effects of chronic administration of AB-FUBINACA on the hippocampus in mice. Our results revealed that the administration of AB-FUBINACA induced a significant impairment in recognition memory associated with histopathological changes in the hippocampus. …"
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Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice
منشور في 2014"…Pretreated groups with chloroform-based fraction reduced significantly the serum levels of AST and ALT. It also reversed the CCl4-induced decrease in SOD, CAT and GST levels thereby reducing significantly hepatic damage. …"
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Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice
منشور في 2015"…Likewise, lung metastasis dramatically increased in the MMTV-PyMT; Mmp8-null mice. Immunohistochemistry revealed that tumors in wild-type, Mmp8-heterozygotes and -null animals had similar vascular density at 8 weeks, but at 10 weeks Mmp8-wild-type tumors had a lower vascularity than their heterozygote and null counterparts. …"
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
منشور في 2021"…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …"
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Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mi...
منشور في 2011"…Bone marrow (BM) transplantation experiments further revealed that LDLR⁻′⁻ mice reconstituted with AEBP₁⁻′⁻/LDLR⁻′⁻ BM cells (LDLR⁻′⁻/KO-BM chimera) display significant reduction of atherosclerosis lesions (en face: 2.0-fold, P = 0.0268; aortic roots: 1.7-fold, P = 0.05) compared with control mice reconstituted with AEBP₁⁺′⁺/LDLR⁻′⁻ BM cells (LDLR⁻′⁻/WT-BM chimera). …"
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Hyper-Hypo study: A Retrospective Observational Study of Neonatal Hypoglycemia Related to Maternal Hypertension
منشور في 2023"…Neonates of hypertensive women were significantly more preterm, had lower birth weight and part of multiple pregnancies. …"
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Renal Function Decline in Recipients and Donors of Kidney Grafts
منشور في 2015"…Results: Decline in renal function was estimated at 1-year post-transplantation and annually thereafter (median follow-up 8 years, range 3.6-18.3), as the mean of the annualized decrease in the glomerular filtration rate. …"
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Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition
منشور في 2003"…Prednisolone-treated groups revealed significantly lower intestinal absorption. However, prednisolone-treated high-carbohydrate (HC) fed rats showed significantly higher weight gain, concomitant with a significant increase in feed efficiency. …"
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Nurses’ work environment and intent to leave in Lebanese hospitals
منشور في 2011"…Results The NWI-R subscale with the lowest mean score related to control. Younger nurses had lower scores on organizational support and career development. …"
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Self-reported awareness and attitude of cancer patients towards clinical nurse coordinators
منشور في 2017"…Participants with higher knowledge scores had better perception indicating a better comprehension about the clinical nurse coordinators’ roles, compared to those with lower knowledge percentage mean scores (β = 0.13, p = .019). …"
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The protective role of lidocaine in surgeries involving trigeminal nerve manipulation: a meta-analysis of trigeminocardiac reflex prevention
منشور في 2025"…The incidence of TCR was significantly lower in the lidocaine group compared to the control group, with a risk ratio of 0.05 (95% CI 0.01 to 0.37, <i>P</i> = 0.003). …"