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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Sleeping habits during COVID-19 induced confinement: A study from Jordan
منشور في 2021"…Majority of the participants (53–59%) reported an increase in most of the sleep parameters except a decrease (49.1%) in daytime sleep. Age was associated with changes in sleeping disturbances during COVID-19 confinement (p < 0.001). …"
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Formation of Trihalomethanes during Seawater Chlorination
منشور في 2010"…Results of kinetic experiments have shown that concentrations of THMs increased rapidly with time during the first half hour. Chlorination of seawater has shown significant increase in total THMs (TTHMs) and in bromoform concentrations. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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A Comprehensive Analysis of Healthcare Big Data Management, Analytics and Scientific Programming
منشور في 2020"…Early decision making based healthcare system has massive potential for dropping the cost of care, refining quality of care, and reducing waste and error. Scientific programming play a significant role to overcome the existing issues and future problems involved in the management of large scale data in healthcare, such as by assisting in the processing of huge data volumes, complex system modelling, and sourcing derivations from healthcare data and simulations. …"
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The impact of an educational program on emergency nurses’ preparedness to care for domestic violence women victims
منشور في 2025"…All the invited nurses attended the educational program. Therefore, the response rate was 100%, and there were no attrition or withdrawal cases during the study. …"
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An arabic picture vocabulary program to develop oral language, visual imagery, and memory skills. (c2012)
منشور في 2016"…The student had received intensive intervention sessions for two months using an adapted version of the Visualizing and Verbalizing Program® by Lindamood-Bell. Pre-test, during-the-intervention-test, and post-test assessment used various formal and informal instruments to accurately measure the student’s progress. …"
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