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Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> and CD4...
منشور في 2019"…In vitro suppression assays were used to determine the ability to suppress naive T cell proliferation in vitro of both CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> and CD4<sup>+</sup>CD25<sup>−</sup>FoxP3<sup>+</sup> T cell sub-populations. …"
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Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors
منشور في 2024"…Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …"
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FoxP3<sup>+</sup> T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets
منشور في 2020"…We discuss the prognostic significance of FoxP3<sup>+</sup> Tregs in different cancers and their potential use as prognostic biomarkers. …"
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Chronic reduction of store operated Ca<sup>2+</sup> entry is viable therapeutically but is associated with cardiovascular complications
منشور في 2022"…</p> <h2>Key points</h2> <ul> <li>A floxed stromal interaction molecule 1 (STIM1) hypomorph mouse model was generated with significant reduction in Ca<sup>2+</sup> influx through store-operated Ca<sup>2+</sup> entry (SOCE), resulting in defective nuclear translocation of nuclear factor of activated T cells, cytokine production and inflammatory response. …"
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Glycine-modified chitosan-embedded silver nanoparticles: a green approach to Pb<sup>2+</sup> adsorption and bioactivity enhancement
منشور في 2024"…The efficiency of SCG nanoparticles in removing Pb<sup>2+</sup> ions was tested using a batch adsorption process. …"
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Deep learning-based modeling of land use/land cover changes impact on land surface temperature in Greater Amman Municipality, Jordan (1980–2030)
منشور في 2024"…The results showed an expansion of urban areas in GAM from 54.13 km2 (6.6%) in 1980 to 374.1 km<sup>2</sup> (45.3%) in 2023. However, agricultural areas decreased from 152.13 km<sup>2</sup> (18.5%) in 1980 to 140.38 km<sup>2</sup> (17%) in 2023, while barren lands decreased from 54.44 km<sup>2</sup> (6.6%) in 1980 to 34.71 km<sup>2</sup> (4.22%) in 2023. …"
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Airway surface liquid volume expansion induces rapid changes in amiloride-sensitive Na<sup>+</sup>transport across upper airway epithelium-Implications concerning the resolution of...
منشور في 2015"…We previously demonstrated that elevation of submucosal hydrostatic pressure increases airway epithelium permeability resulting in ASLV expansion by 500 μL cm<sup>−2</sup> h<sup>−1</sup>. Liquid reabsorption by healthy airway epithelium is regulated by active Na+ transport at a rate of 5 μL cm<sup>−2</sup> h<sup>−1</sup>. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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Multivariate analysis for FTIR in understanding treatment of used cooking oil using activated carbon prepared from olive stone
منشور في 2020"…Two FTIR absorption peaks were used for the oil evaluation, namely 3007–3009 cm<sup>-1</sup>, which is related to C-H symmetric stretching vibration of the <i>cis</i> double bonds, and ~1743 cm<sup>-1</sup>, which is related to = CH and ester carbonyl stretching vibration of the functional groups of the triglycerides, C = O. …"
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