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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Machine Learning Approach for Effective Ranking of Researcher Assessment Parameters
منشور في 2023"…During the individual evaluation of each parameter, we uncovered several intriguing patterns in the data. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Experimental Setup to Validate the Effects of Major Environmental Parameters on the Performance of FSO Communication Link in Qatar
منشور في 2018"…We present a comparison between the FSO performances for the different seasons in terms of Packet Delivery Ratio (PDR). We notice a significant difference in the behavior of FSO during summer and winter seasons. …"
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Correlating process parameters to thrust forces and torque in the friction stir processing of AZ31B
منشور في 2014"…The correlation equations were found to be able to predict the experimentally measured forces during friction stir processing with good statistical significance with average estimate errors of 6.2% and 5.4% for the thrust force and torque, respectively. …"
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An Experimental Investigation of the Effects of Dressing and Grinding Parameters on Sustainable Grinding of Inconel 738 Used for Automated Manufacturing
منشور في 2023"…Additionally, it has been found from the experimental results that applying a single-edge dresser generates finer topography on the grinding wheel and, consequently, has a better surface finish in the grinding process compared to the multipoint diamond dressing tool with the same dressing and grinding parameters. In other words, increasing the dressing feed rate during dressing of the grinding wheel using a multipoint dresser makes a finer wheel surface topography and as a result decreases the surface roughness of the ground workpiece compared to a single-edge dresser. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Sleeping habits during COVID-19 induced confinement: A study from Jordan
منشور في 2021"…<p dir="ltr">Sleep can significantly modulate the immune response to infectious agents. …"
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Optimizing recycled PET 3D printing using Taguchi method for improved mechanical properties and dimensional precision
منشور في 2025"…Preserving the mechanical and physical properties of recycled PET (rPET) during printing is essential. This study used a design of experiments approach to optimize AM parameters, including nozzle temperature, bed temperature, and print speed. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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