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Association between Healthy Lifestyle Index and Cognitive decline In Community- Dwelling Lebanese Older Adults
منشور في 2021"…Objective: Normal aging is often associated with cognitive deterioration in older adults, but the prevalence of cognitive decline like cognitive impairment, Alzheimer’s disease and dementia has been increasing lately. …"
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masterThesis -
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Lower limb EMG activation during reduced gravity running on an incline. Speed matters more than hills irrespective of indicated bodyweight
منشور في 2021"…Increasing running speed was associated with the largest change in activity, with smaller effects for increasing bodyweight and inclination. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Prevalence and risk of cognitive impairment among patients with asthma: A systematic review and meta‐analysis
منشور في 2025"…The results underscored the substantial correlation between asthma and heightened risks of cognitive decline, dementia, and Alzheimer's disease.</p><h3>Conclusion</h3><p dir="ltr">This review found a notable association between asthma and an increased risk of cognitive decline, including dementia and Alzheimer's disease. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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Analyzing the Influence of Climate and Anthropogenic Development on Vegetation Cover in the Coastal Ecosystems of GCC
منشور في 2025"…Our results revealed significant changes in land cover, as seen by an increase in artificial built-up areas by 15.5% in two decades and a corresponding decrease in bareland and dense vegetation. …"
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Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease
منشور في 2015"…For patients not sufficiently controlled on a single long-acting bronchodilator, a combination of different bronchodilators has shown a significant increase in lung function. Tiotropium, a once-daily dosing LAMA, demonstrated sustained improvements in lung function as well as improved health-related quality of life, reduced exacerbations, and increased survival without altering the rate of decline in the mean forced expiratory volume in 1 second (FEV1) with fairly tolerable side effects. …"
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article -
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Screen Time Soars and Vision Suffers: How School Closures During the Pandemic Affected Children and Adolescents’ Eyesight
منشور في 2024"…Furthermore, logistic regression analysis showed that local students and those with a history of visual disturbances were 1.7 times (AOR: 1.73, 95%CI 1.18–2.54, <i>p</i> = 0.005) and 2.5 times (AOR: 2.52, 95%CI 1.69–3.76, <i>p</i> < 0.001) more likely to experience decline of visual acuity respectively. School closures in Qatar were associated with a significant increase in screen time among students and a notable decline in their visual acuity. …"
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Does the CEO effect differ in times of crisis? Evidence from US and China during the global financial crisis
منشور في 2024"…Utilizing multilevel modeling on a 15-year dataset of US firms and assessing three performance metrics, we identify a significant decline (increase) in the CEO effect on accounting-based (market-based) performance measures (measure) from the pre-crisis to the crisis period, followed by a significant rebound post-crisis. …"
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article -
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Board changes and CEO turnover
منشور في 2014"…For firms that decrease independence, the CEO turnover performance sensitivity significantly decreases following SOX. …"
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article -
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Viability of Amazon’s driven innovations targeting shoppers’ impulsiveness
منشور في 2020"…The findings show that while retailers' tech-driven solutions would increase shoppers' impulsiveness, and hence sales, their continued interaction with such purchasing solutions would decline over time, making the overall innovation cycle much shorter.…"
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article -
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Cryptocurrency comovements and crypto exchange movement: The relocation of Binance
منشور في 2022"…Using multivariate regression analysis, our results show that Binance experienced a significant decline in comovement with its origin market after moving to Malta. …"