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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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The Role of Project Management Soft Skills in Increasing Project Success
منشور في 2017"…As the world economy shifts towards an increasingly globalised market, the degree of competition becomes a more significant challenge which organisations face. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Effect of increasing the number of anchors on the flexural performance of FRP-strengthened RC beams
منشور في 2024"…Results showed that increasing the number of anchors significantly improved the flexural behavior of the strengthened beam in terms of the beam's response at failure and the strain utilized in the FRP laminates. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients
منشور في 2016"…<p dir="ltr">Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival in cancer patients. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Use of Ultrasound and Ionic Liquids to Enhance the Extractive Desulfurization of Oils
منشور في 2016احصل على النص الكامل
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Effects of BIM in Enhancing Prefabricated Construction
منشور في 2021احصل على النص الكامل
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Cognitive Vigilance Enhancement using Audio Stimulation of Pure Tone at 250 Hz
منشور في 2021"…The entropy measures show that the temporal profile of the EEG signals has significantly increased with VE. The classification results showed that SVM technique with DE features across all frequency bands can detect VE levels with accuracy varying between (92.10±02.24)% to (98.32±01.14)%, sensitivity of (92.50±02.33)% to (98.66±01.00)%, and specificity of (91.70±02.32)% to (97.99±01.05)%. …"
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Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
منشور في 2019"…In both cell-free and cellular models of α-synuclein aggregation, after administration of DHM and Sal B, we observed significant inhibition of α-synuclein accumulation and aggregation. …"