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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
منشور في 2020"…However, only in lower dose of sumac were significant decreases in the expression of oncogenic miR210 and increase of tumor-suppressive miR145 (miR21, miR22, and miR155 were not changed) observed. …"
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Exploring urban growth–climate change–flood risk nexus in fast growing cities
منشور في 2022"…Surveying showed that, between 1984 and 2020, urban areas grew by 777%, and bare lands decreased by 54.7%. In addition, Doha witnessed various climatic changes with a notable increase in air temperature (+ 8.7%), a decrease in surface wind speed (− 19.5%), and a decrease in potential evapotranspiration losses (− 33.5%). …"
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Effect of COVID-19 on the Generation of Waste in Marrakech, Morocco
منشور في 2021"…</p><h3>Results</h3><p dir="ltr">The analysis of solid waste tonnage in 2019 and 2020 showed that the lockdown had a significant impact on the various wastes; with a 27.61% decrease for household waste, 6.27% decrease in the case of green waste, and 57.40% decrease for construction and demolition waste.…"
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Psychological inoculation against problematic social media use among adolescents: An experimental study
منشور في 2025"…The passive inoculation group showed a significant decrease in deception only. No changes were observed in the control group. …"
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Initial approximation of the implications for architecture due to climate change
منشور في 2019"…In general, it can be concluded that future heating demand could decrease (7–52%), while cooling demand could increase significantly (up to 1050%). …"
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Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
منشور في 2022"…Functional assays demonstrated an increase in lipid accumulation, bile acid synthesis and glycerol production, while a decrease in glucose uptake, glycogen storage, and Albumin secretion. …"
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Fourier Transform Infrared Imaging—A Novel Approach to Monitor Bio Molecular Changes in Subacute Mild Traumatic Brain Injury
منشور في 2021"…Significant decrease in methyl content and a significant increase in olefinic content were observed in Co and CC regions of mTBI rat brain tissues. …"
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Disrupted harvests: how Ukraine – Russia war influences global food systems – a systematic review
منشور في 2024"…The decrease in food availability led to increased food prices and inflation, which, combined with the disruption of agri-food trade, markets, and supply chains, affected food access, especially for the poor and vulnerable people and groups. …"
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Formation of Trihalomethanes during Seawater Chlorination
منشور في 2010"…Chlorination of seawater has shown significant increase in total THMs (TTHMs) and in bromoform concentrations. …"
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Reinforced steering Evolutionary Markov Chain for high-dimensional feature selection
منشور في 2024"…(iv) Agents moving in the right way are rewarded with an increase in their associated transition probability, while the agents going in the wrong direction are discouraged with a decrease in their associated transition probabilities; this promotes the establishment of an equilibrium state and leads to convergence. …"
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Investigating the Impact of Salinity Variations on Aerobic Granules and Activated Sludge Flocs: Emphasis on Performance Monitoring and Identification of Influential Salinity Compon...
منشور في 2022"…Ionic strength affected the morphology the most, where ionic strength disrupted the production of EPS components leading to increased negative sludge surface charge, poorer sludge adhesion and eventually significant reduction in sludge settling abilities. …"
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
منشور في 2021"…The results of the conducted computational experiments indicate that an increase in infrastructure investment through high speed chargers can significantly decrease the size of the necessary fleets. …"
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Multilayer Reversible Data Hiding Based on the Difference Expansion Method Using Multilevel Thresholding of Host Images Based on the Slime Mould Algorithm
منشور في 2022"…As a result, the embedding capacity in each class can increase by reducing the value of the difference between two consecutive pixels, and the distortion of the marked image can decrease after inserting the personal data using the DE method. …"
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Effects of ethanol addition to diesel–biodiesel blends on the CI engine characteristics
منشور في 2024"…Biodiesel addition significantly increases carbon monoxide (CO) emissions, reaching an average of 190% across all speeds. …"