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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Detection of statistically significant network changes in complex biological networks
منشور في 2017"…</p><h3>Conclusions</h3><p dir="ltr">We show that our network differencing procedure can effectively and efficiently detect statistical significant network re-wirings in different conditions. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Plant Disease Classifier: Detection of Dual-Crop Diseases Using Lightweight 2D CNN Architecture
منشور في 2023"…Cotton is another essential cash crop because most farmers grow it in huge quantities. However, many diseases reduce the quality and quantity of tomato and cotton crops, resulting in a significant loss in production and productivity. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Classification and segmentation of kidney MRI images for chronic kidney disease detection
منشور في 2024"…<p>Chronic Kidney Disease (CKD) is a common ailment with significant public health implications, underscoring the critical importance of early detection and diagnosis for effective management. …"
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Plant Leaf Disease Detection Using Ensemble Learning and Explainable AI
منشور في 2024"…This study introduces an AI (Artificial Intelligence) model that detects and explains plant diseases through image analysis. …"
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Mulberry Leaf Disease Detection Using CNN-Based Smart Android Application
منشور في 2024"…However, mulberry trees are highly susceptible to diseases, spreading rapidly and causing significant losses. …"
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Cutting‐edge technologies for detecting and controlling fish diseases: Current status, outlook, and challenges
منشور في 2024"…However, the industry is facing several difficulties, including infectious diseases, the most significant limiting factor for aquaculture expansion. …"
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An End-to-End Deep Learning Framework for Real-Time Denoising of Heart Sounds for Cardiac Disease Detection in Unseen Noise
منشور في 2023"…The proposed deep learning-based PCG denoising approach is a pioneering study that can significantly improve the accuracy of computer-aided auscultation systems for detecting cardiac diseases in noisy, low-resource hospitals and underserved communities. …"
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Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage
منشور في 2022"…<h3>Background and Objectives</h3><p dir="ltr">Robust biomarkers that can mirror Parkinson disease (PD) are of great significance. In this study, we present a novel approach to investigate disease-associated α-synuclein (αSyn) aggregates as biomarkers of PD clinical stage.…"
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