A genome-wide DNA methylation signature for SETD1B-related syndrome حسب I. M. Krzyzewska (18614968)

"…Here, we identify a specific hypermethylation signature associated with loss of function mutations in theSETD1Bgene which may be used as an epigenetic marker supporting the diagnosis of syndromicSETD1B-related diseases. We demonstrate the clinical utility of this unique epi-signature by reclassifying previously identifiedSETD1BVUS (variant of uncertain significance) in two patients.…"

Cross-sectional proteomic expression in Parkinson's disease-related proteins in drug-naïve patients vs healthy controls with longitudinal clinical follow-up حسب Ilham Yahya Abdi (17870462)

"…The analysis identified 73 differentially expressed proteins (DEPs) of which 14 proteins were confirmed as stable potential diagnostic markers using machine learning tools. …"

Expression of microRNA in follicular fluid in women with and without PCOS حسب Alexandra E. Butler (6189536)

"…Ingenuity pathway assessment revealed that 12 of the significantly altered miRNA related to reproductive pathways, 12 miRNA related to the inflammatory disease pathway and 6 were implicated in benign pelvic disease. …"

Cytosolic Phospholipase A2-Mediated ICAM-1 Expression Is Calcium Dependent حسب Abdalla, Eddie

"…Some human malignancies such as virus-related hepatocellular cancer arise in a setting of chronic inflammation. …"
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Gene expression data analysis identifies multiple deregulated pathways in patients with asthma حسب Reem H. Alrashoudi (18629731)

"…The present study integrated four asthma-related gene expression datasets from the Gene Expression Omnibus and identified immune-gene signatures associated with asthma development, severity, or response to treatment. …"

Mixed precision iterative refinement with adaptive precision sparse approximate inverse preconditioning حسب Noaman Khan (19810050)

"…<p dir="ltr">Hardware trends have motivated the development of mixed precision algorithms in numerical linear algebra, which aim to decrease runtime while maintaining acceptable accuracy. …"

Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery حسب Stephen L. Atkin (6684368)

"…Functional pathways of the altered microRNAs were associated with diabetes-, pituitary-, and liver-related disease, with expression in natural killer cells, and pivotal intestinal pathology suggesting possible mechanistic roles in early diabetes responses following bariatric surgery.…"

A jojoba (Simmondsia chinensis) seed cake extracts express hepatoprotective activity against paracetamol-induced toxicity in rats حسب Firas Feki (17545638)

"…The PC intoxication altered the serum biomarkers, the oxidative status, and the Tumor necrosis factor alpha (TNF-α), Bax and Bcl-2 protein expressions of tested animals. In addition, the histological analysis of liver tissues proved significant injury and hepatocellular necrosis. …"

Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women حسب Vijay, Ganji

"…In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. In conclusion, serum 25-hydroxyvitamin D was inversely associated with adiposity measures and non-linearly associated to bone mass in postmenopausal Qatari women.…"
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women حسب Vijay Ganji (8710491)

"…In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. In conclusion, serum 25-hydroxyvitamin D was inversely associated with adiposity measures and non-linearly associated to bone mass in postmenopausal Qatari women.…"

When digital spaces matter: The influence of uniqueness and place attachment on self-identity expression with brands using generative AI on the metaverse حسب Farah, Maya F.

"…This underscores the importance of studying their significant impact on customer experiences in the Metaverse. …"
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The identification of highly upregulated genes in claudin-low breast cancer through an integrative bioinformatics approach حسب Hatem, Zayed

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Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers حسب Husseini, Ghaleb

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Immune-related 3-lncRNA signature with prognostic connotation in a multi-cancer setting حسب Shimaa Sherif (12862990)

"…</p><h3>Methods</h3><p dir="ltr">We developed a multi-step process to identify immune-related long non-coding RNA signatures with prognostic connotation in multiple TCGA solid cancer datasets.…"

Circulating and Tumor-Infiltrating Immune Checkpoint-Expressing CD8+ Treg/T Cell Subsets and Their Associations with Disease-Free Survival in Colorectal Cancer Patients حسب Alhasan Alsalman (14802873)

"…We investigated the expression levels of key immune checkpoints (ICs) and Treg-related markers in CD8+ T cells. …"

MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM حسب Ramesh Elango (7542068)

"…Interestingly, interrogation of the expression levels of hsa-miR-205 and hsa-miR-214 in the METABRIC breast cancer dataset revealed significantly poor overall survival in patients with downregulated expression of miR-205 [HR = 0.75 (0.61–0.91)], p = 0.003 and hsa-miR-214 [HR = 0.74 (0.59–0.93) p = 0.008]. …"

Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer حسب Rasha M. Sareyeldin (18131371)

"…Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. …"

Genome-wide differential expression profiling of long non-coding RNAs (lncRNAs) in pancreatic cells derived from FOXA2-/- iPSCs حسب Ahmed K. Elsayed (13275302)

"…Furthermore, these data suggest that the FOXA2-related defective pancreatic islet development is associated with significant alterations in the expression profile of lncRNAs.…"

Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system حسب Frank Schmidt (207186)

Malignant peritoneal mesothelioma interactome with 417 novel protein–protein interactions حسب Kalyani B. Karunakaran (12478431)

"…The MPeM interactome overlapped significantly with the malignant pleural mesothelioma interactome, revealing shared molecular pathways.…"