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Revisiting high-density lipoprotein cholesterol in cardiovascular disease: Is too much of a good thing always a good thing?
منشور في 2024"…Despite the correlation between low high-density lipoprotein cholesterol (HDLC) and heightened CVD risk, HDL-raising therapies have yet to showcase significant clinical benefits. …"
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Tumor-Infiltrating Lymphoid Cells in Colorectal Cancer Patients with Varying Disease Stages and Microsatellite Instability-High/Stable Tumors
منشور في 2021"…We investigated the expression of immune checkpoints (ICs) on lymphoid populations within the CRC TME and compared with cells from normal colon tissues using samples from 50 patients with varying disease stages. We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4+ and CD4+CD8+ double positive T cells were higher, while CD8+ T cells and CD4−CD8− double negative T cells were significantly lower in CRC tumors. …"
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Reduction of laboratory utilization in the intensive care unit
منشور في 2016"…Conclusion: A simple technique of resident, nursing, and ancillary staff education, combined with alterations in order sets using electronic medical records, can lead to a sustained reduction in laboratory test utilization over time and to significant cost savings without affecting patient safety.…"
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Association of coronary artery disease and chronic kidney disease in Lebanese population
منشور في 2015"…This correlation remained highly significant despite considerable inter-patient variability and was at its highest at the most advanced stages of both diseases. …"
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L1-CAM knock-down radiosensitizes neuroblastoma IMR-32 cells by simultaneously decreasing MycN, but increasing PTEN protein expression
منشور في 2016"…Childhood neuroblastoma is one of the most malignant types of cancers leading to a high mortality rate. These cancerous cells can be highly metastatic and malignant giving rise to disease recurrence and poor prognosis. …"
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Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage
منشور في 2022"…<h3>Background and Objectives</h3><p dir="ltr">Robust biomarkers that can mirror Parkinson disease (PD) are of great significance. In this study, we present a novel approach to investigate disease-associated α-synuclein (αSyn) aggregates as biomarkers of PD clinical stage.…"
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Tryptophanyl-tRNA synthetase-1 (WARS-1) depletion and high tryptophan concentration lead to genomic instability in Caenorhabditis elegans
منشور في 2024"…Our result demonstrates that exposing C. elegans to a high tryptophan dosage leads to DNA damage checkpoint activation and a significant increase in the tryptophan metabolites. …"
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Stemming cardiovascular diseases in Qatar
منشور في 2015"…Many of the heart attack and stroke patients had diabetes, hypertension, high cholesterol, and/or were smokers, whereas controls were much less likely to have these factors.…"
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Aortic stiffness, kidney disease, and renal transplantation
منشور في 2009"…In subjects with chronic kidney disease (CKD), treatment of high systolic blood pressure is a key element in preventing disease progression and the occurrence of cardiovascular (CV) events. …"
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Parkinson’s disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes
منشور في 2024"…<p dir="ltr">Genome-wide association studies suggest significant overlaps in Parkinson’s disease (PD) and schizophrenia (SZ) risks, but the underlying mechanisms remain elusive. …"
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Dietary patterns in cardiovascular diseases prevention and management
منشور في 2014"…The significance of this type of research to primary care physicians is also highlighted. …"
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Olodaterol for the treatment of chronic obstructive pulmonary disease
منشور في 2016"…Olodaterol (Striverdi Respimat, Boehringer Ingelheim), a LABA with high selectivity for β2-adrenergic receptors, is indicated for the treatment of chronic obstructive pulmonary disease (COPD); the recommended dose is 5 µg, to be delivered once daily via the Respimat inhaler. …"
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Nurse-Led System-wide Unit-based Hospital Acquired Pressure Injury (HAPI) Reduction Project
منشور في 2024"…Medical devices contribute to approximately 50% of these total HAPI. HAPI is a significant patient safety issue in hospitalized patients and can lead to increased healthcare costs and a decreased quality of life for patients . …"
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Theoretical insight into effect of cation–anion pairs on CO<sub>2</sub> reduction on bismuth electrocatalysts
منشور في 2020"…The adsorption energy (Eads) and work function (Wf) of the anions increases with decreasing anion size (i.e., Cl<sup>−</sup> > Br<sup>−</sup> > I<sup>−</sup>). …"
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Minor Intron Splicing from Basic Science to Disease
منشور في 2021"…Consequently, uncovering how mi-INTs splicing is regulated in a tissue-specific manner would allow for better understanding of disease pathogenesis and pave the way for novel therapies, which we highlight in this review.…"
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Chronic reduction of store operated Ca<sup>2+</sup> entry is viable therapeutically but is associated with cardiovascular complications
منشور في 2022"…</p> <h2>Key points</h2> <ul> <li>A floxed stromal interaction molecule 1 (STIM1) hypomorph mouse model was generated with significant reduction in Ca<sup>2+</sup> influx through store-operated Ca<sup>2+</sup> entry (SOCE), resulting in defective nuclear translocation of nuclear factor of activated T cells, cytokine production and inflammatory response. …"
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Association between dental diseases and history of stroke in the United States
منشور في 2023"…Multiple logistic regression modeling was used to estimate the effect of these dental diseases on the self-reported history of stroke with intent to adjust for the other potential determinants: age, sex, race, marital status, health insurance, education, exercise, body mass index, smoking, alcohol, hypertension, high serum cholesterol, and diabetes.…"
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Allergic rhinitis: Disease characteristics and coping measures in Saudi Arabia
منشور في 2019"…Background Despite allergic rhinitis (AR) being a highly prevalent disease, according to literature, it is often underdiagnosed or undertreated. …"
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