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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors
منشور في 2024"…Single-cell analysis revealed high RFX6 expression levels in endocrine clusters across various hESC-derived pancreatic differentiation stages. Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …"
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Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity
منشور في 2023"…</p> <p>Results: The BCAA-restricted diet significantly reduced circulating BCAA concentrations by ~50% i.e., baseline 437 ± 60 to 217 ± 40 µmol/L (p < 0.005). …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. …"
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Roles of the pharmacist in the use of safe and highly effective long‐acting reversible contraception
منشور في 2014"…Use of long-acting reversible contraceptive (LARC) methods has been increasing in recent years after efforts to educate providers and patients. …"
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STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
منشور في 2023"…Interestingly, NFAT1 is significantly downregulated in STIM1-KO cells and overexpression of NFAT1 reversed the enhanced migration of STIM1-KO cells. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Otosyphilis: A rare case of reversible hearing loss in a young man with secondary syphilis
منشور في 2023"…<h3>Background</h3><p dir="ltr">Over the last decade, it has been noticed a significant increase in the number of cases of syphilis with a concurrent increased number of patients presenting with syphilis-related complications. …"
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A Comprehensive Review on Membrane Fouling: Mathematical Modelling, Prediction, Diagnosis, and Mitigation
منشور في 2021"…Membrane-based separation has gained increased popularity over the past few decades, particularly reverse osmosis (RO). …"
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Inland Treatment of the Brine Generated from Reverse Osmosis Advanced Membrane Wastewater Treatment Plant Using Epuvalisation System
منشور في 2013"…The reverse osmosis (RO) brine generated from the Al-Quds University wastewater treatment plant was treated using an epuvalisation system. …"
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Comparative life-cycle assessment of reverse osmosis and microalgae-based treatment for hypersaline oilfield produced water
منشور في 2025"…However, it also presented important trade-offs, including a 2.19-fold increase in land use, a 9.7-fold increase in marine eutrophication driven by the nitrogen content of the glucose feedstock, and higher human carcinogenic toxicity. …"
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Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice
منشور في 2018"…Selenium significantly decreased the number of aggregated tau-positive neurons and astrogliosis, without globally affecting amyloid plaques, in the hippocampus of 3xTg-AD mice. …"
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Response of cauliflower (<i>Brassica oleracea</i> L.) to nitric oxide application under cadmium stress
منشور في 2022"…The concentration of malondialdehyde (MDA) and Cd accumulation (roots and shoots) increased significantly (P < 0.05) under the increasing levels of Cd in all genotypes of B. oleracea while antioxidant (enzymatic or non-enzymatic) capacity and nutritional status of the plants was decreased with varying levels of Cd in the sand. …"
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Strategies for the use and interpretation of functionalized reverse osmosis membranes with improved antifouling and anti-scaling properties for the desalination process
منشور في 2024"…The membrane fouling caused by the constituents of feedwater affects the performance of the reverse osmosis (RO) membrane by partially or completely blocking the membrane pores and increasing the system's operating cost. …"