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يعرض 1 - 20 نتائج من 428 نتيجة بحث عن '(( significantly increased decrease ) OR ( significant aggregate level ))', وقت الاستعلام: 0.10s تنقيح النتائج
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    The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

    منشور في 2019
    "…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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    Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid حسب Keita Kakuda (9668898)

    منشور في 2019
    "…We confirmed that this assay could detect α-synuclein aggregates prepared in vitro and also aggregates released from cultured cells. …"
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    A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

    منشور في 2024
    "…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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    Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

    منشور في 2022
    "…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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    Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage حسب Nour Majbour (3528548)

    منشور في 2022
    "…<h3>Background and Objectives</h3><p dir="ltr">Robust biomarkers that can mirror Parkinson disease (PD) are of great significance. In this study, we present a novel approach to investigate disease-associated α-synuclein (αSyn) aggregates as biomarkers of PD clinical stage.…"
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    Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion حسب Khoury, Nathalie

    منشور في 2014
    "…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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    article
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    Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy حسب Jia-Zhen Wu (6844793)

    منشور في 2019
    "…Cells were co-transfected with a C-terminal modified α-synuclein (SynT) and synphilin-1, and then treated with DHM (10 μM) and Sal B (50 μM) 16 hours after transfection; levels of α-synuclein aggregation decreased significantly (68% for DHM and 75% for Sal B). …"
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    An investigation into the potential action of polyphenols against human Islet Amyloid Polypeptide aggregation in type 2 diabetes حسب Anns Mahboob (17337886)

    منشور في 2023
    "…<p dir="ltr">Type 2 diabetes (T2D), a chronic metabolic disease characterized by hyperglycemia, results in significant disease burden and financial costs globally. …"
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    Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells حسب Shebaby, Wassim N.

    منشور في 2014
    "…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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    article
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    Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease حسب Hidetomo Murakami (6105284)

    منشور في 2019
    "…Lower CSF levels of Aβ1–42, total tau and P-tau181p were significantly related to worsening of some motor and/or cognitive functions. …"
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    Date palm (Phoenix dactylifera L.) fruit's polyphenols as potential inhibitors for human amylin fibril formation and toxicity in type 2 diabetes حسب Ali Chaari (827168)

    منشور في 2020
    "…</p><h3>Method</h3><p dir="ltr">In this study, we used a broad biophysical approach, using cell biology techniques and bioinformatic tools, to demonstrate that various polyphenols from date palm (<i>Phoenix dactylifera</i> L.) fruit significantly inhibited hIAPP aggregation and cytotoxicity.…"
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    Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002) حسب Berberi, Rania

    منشور في 2002
    "…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …"
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    masterThesis
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    Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats حسب Daher, Costantine F.

    منشور في 2015
    "…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …"
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    article
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