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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…This is specifically relevant in designing assays that require bioluminescence for extended periods, such as in the case of biosensors designed for monitoring slow enzymatic or <u>cellular signaling</u> reactions, without necessitating multiple rounds of luciferase substrate addition or any specialized reagents that result in increased assay costs. In the current manuscript, we report a mutant NLuc that possesses a stable and prolonged bioluminescence activity, albeit lower than the wild-type NLuc, and envisage a wider application of the mutant NLuc in designing biosensors for monitoring slower biological and biomedical events.…"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines
منشور في 2018"…Complex 1 demonstrated only marginal activity in the dark; its cytotoxicity increased significantly upon photoactivation with a high phototoxicity index (PI = [IC50 dark]/[IC50 light]) ranging from 39.2‐fold in A549 to over 100‐fold in MDA‐MB‐231. …"
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Potential Medical Applications of Chitooligosaccharides
منشور في 2022"…COS can be produced through enzymatic conversions using chitinases, physical and chemical applications, or a combination of these strategies. COS is of significant interest for pharmacological and medical applications due to its increased water solubility and non-toxicity, with a wide range of bioactivities, including antibacterial, anti-inflammatory, anti-obesity, neuroprotective, anticancer, and antioxidant effects. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Network Analysis and its Applications in Financial and Digital Assets
منشور في 2025احصل على النص الكامل
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Privacy-preserving artificial intelligence in healthcare: Techniques and applications
منشور في 2023"…<p>There has been an increasing interest in translating artificial intelligence (AI) research into clinically-validated applications to improve the performance, capacity, and efficacy of healthcare services. …"
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Augmented Reality and its Applications in Education: A Systematic Survey
منشور في 2023"…<p dir="ltr">The use of technology, especially mobile phones, has significantly increased over the past few decades and has become an essential element in our daily lives. …"
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The use of multi-task learning in cybersecurity applications: a systematic literature review
منشور في 2024"…Despite government and corporate efforts, cybersecurity remains a significant concern. The application of multi-task learning (MTL) in cybersecurity is a promising solution, allowing security systems to simultaneously address various tasks and adapt in real-time to emerging threats. …"
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Investigating the suitability of poly tetraarylphosphonium based anion exchange membranes for electrochemical applications
منشور في 2021"…<div><p>Anion exchange membranes (AEMs) are becoming increasingly common in electrochemical energy conversion and storage systems around the world (EES). …"
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Just-in-time defect prediction for mobile applications: using shallow or deep learning?
منشور في 2023"…<p dir="ltr">Just-in-time defect prediction (JITDP) research is increasingly focused on program changes instead of complete program modules within the context of continuous integration and continuous testing paradigm. …"
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Effect of Mg incorporation on the properties of PCL/Mg composites for potential tissue engineering applications
منشور في 2024"…Additionally, the weight loss during <i>in vitro</i> degradation showed that the presence of Mg had significantly increased the degradation rate of composite samples. …"