يعرض 1 - 20 نتائج من 426 نتيجة بحث عن '(( significantly increased decrease ) OR ( significant binding site ))', وقت الاستعلام: 0.09s تنقيح النتائج
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    Coevolving residues distant from the ligand binding site are involved in GAF domain function حسب Wesam S. Ahmed (10170053)

    منشور في 2025
    "…Here, we combine computational and experimental approaches to demonstrate that two highly coevolving residues, L267 and F295, distant from the ligand binding site, play a critical role in GAF domain allostery. …"
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    The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

    منشور في 2019
    "…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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    A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

    منشور في 2024
    "…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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    Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

    منشور في 2022
    "…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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    Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion حسب Khoury, Nathalie

    منشور في 2014
    "…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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    article
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    In silico virtual screening of lead compounds for major antigenic sites in respiratory syncytial virus fusion protein حسب Shilu Mathew (625826)

    منشور في 2022
    "…Using in silico virtual screening, we identified potential RSV inhibitors that bind two major antigenic sites on the RSV F protein. …"
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    Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells حسب Shebaby, Wassim N.

    منشور في 2014
    "…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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    article
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    Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002) حسب Berberi, Rania

    منشور في 2002
    "…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …"
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    masterThesis
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    Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats حسب Daher, Costantine F.

    منشور في 2015
    "…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …"
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    A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle حسب Sanjay Kumar (8853)

    منشور في 2022
    "…</p><p dir="ltr">In contrast, hesperidin formed a more significant number of hydrogen bonds with PLpro. These observations were complimented by the 100 ns molecular dynamics simulation and binding free energy analysis, which showed a considerable stability of docked bioflavonoids in the active site of SARS-CoV-2 target proteins. …"
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    Occupational Violence at Lebanese Emergency Departments حسب Dimassi, Hani

    منشور في 2011
    "…Exposure to verbal abuse was associated with serious outcomes including significantly higher levels of occupational burnout and an increased likelihood to quit current job. …"
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    article
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