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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Exploring the Significance of Publication-Age-Based Parameters for Evaluating Researcher Impact
منشور في 2023"…Currently, the state-of-the-art evaluation of these indices is based on hypothetical scenarios and the limited and unfair distribution of researcher records in the datasets. In addition, these indices are often evaluated using dissimilar datasets, making it challenging to accurately compare their contributions and significance. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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R<sup>2</sup>S100K: Road-Region Segmentation Dataset for Semi-supervised Autonomous Driving in the Wild
منشور في 2024"…To this end, we introduce Road Region Segmentation dataset (R<sup>2</sup>S100K)—a large-scale dataset and benchmark for training and evaluation of road segmentation in aforementioned challenging unstructured roadways. …"
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Image-Based Air Quality Estimation Using Convolutional Neural Network Optimized by Genetic Algorithms: A Multi-Dataset Approach
منشور في 2025"…<p dir="ltr">Air pollution poses significant threats to human health and the environment, making effective monitoring increasingly essential. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Addressing Challenges of Distance Learning in the Pandemic with Edge Intelligence Enabled Multicast and Caching Solution
منشور في 2022"…While exploring the opportunities of EI-enabled distance learning, we demonstrate a significant reduction in network operator resource utilization and an increase in user QoE for VNF based multicast transmission.…"
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Deep learning for brain electron microscopy segmentation: Advances, challenges, and future directions in connectomics and ultrastructure analysis
منشور في 2025"…These advances drive innovation in 3D computer vision, establish new benchmarks for volumetric instance segmentation, and address fundamental challenges in processing massive biological datasets. …"
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Bridging Innovation and Security: Advancing Cyber-Threat Detection in Sustainable Smart Infrastructure
منشور في 2025"…In response to these challenges, this paper proposes a novel approach utilizing Deep Learning (DL) models for multi-class threat detection in SI environments. …"
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Reinforced steering Evolutionary Markov Chain for high-dimensional feature selection
منشور في 2024"…<p>The increasing accessibility of extensive datasets has amplified the importance of extracting insights from high-dimensional data. …"
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YOLO-DefXpert: An Advanced Defect Detection on PCB Surfaces Using Improved YOLOv11 Algorithm
منشور في 2025"…Compared to the standard YOLOv11 model, the proposed YOLO-DefXpert attained an improvement of 9.3% and 13.2% in mAP50 and mAP95, an 11.25% increase in frames per second, and a 69.85MB decrease in model size. …"