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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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The use of multi-task learning in cybersecurity applications: a systematic literature review
منشور في 2024"…This paper outlines various models utilized in the context of multi-task learning within cybersecurity and presents several challenges in this field.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Deep Learning in LncRNAome: Contribution, Challenges, and Perspectives
منشور في 2020"…<p dir="ltr">Long non-coding RNAs (lncRNA), the pervasively transcribed part of the mammalian genome, have played a significant role in changing our protein-centric view of genomes. …"
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Medical and Health Sciences Librarians: New roles and challenges
منشور في 2024"…In addition to traditional library tasks, these specialized librarians contribute significantly to improving health outcomes by facilitating access to vital information and supporting evidence-based practice. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Optimizing Energy Consumption In Cloud Datacenters
منشور في 2024احصل على النص الكامل
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Implementing a collaborative care model for child and adolescent mental health in Qatar: Addressing workforce and access challenges
منشور في 2024"…<p>Child and adolescent mental health disorders in Qatar remain significantly underserved due to a critical shortage of specialists, stigma, and logistical barriers. …"
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Navigating Anti Money Laundering Complexities: Evidence from the UAE
منشور في 2024احصل على النص الكامل
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Zooming Into Clarity: Image Denoising Through Innovative Autoencoder Architectures
منشور في 2024"…The ResoFocus Autoencoder is designed to optimize and denoise upsized images, while the FragmentumZoom Autoencoder targets small image segments to enhance denoising tasks. Empirical evaluations on diverse datasets, including CelebA and Autism Face data, demonstrate significant improvements in the Peak Signal-to-Noise Ratio (PSNR) and Structural Similarity Index Measure (SSIM). …"
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
منشور في 2002"…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …"
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
منشور في 2015"…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …"
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article