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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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A novel deep learning identifier for promoters and their strength using heterogeneous features
منشور في 2024"…The proposed method utilizes five distinct features, such as word2vec, k-spaced nucleotide pairs, trinucleotide propensity-based features, trinucleotide composition, and electron–ion interaction pseudopotentials, to extract the hidden patterns from the DNA sequence. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Relational pre‑impact assessment of conventional housing features and carbon footprint for achieving sustainable built environment
منشور في 2022"…Therefore, this research aims to explore the relationship between the physical features of the built facil ity and the resulting carbon footprint for conventional housing designs. …"
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Kidney Ensemble-Net: Enhancing Renal Carcinoma Detection Through Probabilistic Feature Selection and Ensemble Learning
منشور في 2024"…To address these challenges, we developed a novel computational framework named Kidney Ensemble-Net, designed to enhance the accuracy of renal carcinoma classification. …"
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Willingness to pay for digital wellbeing features on social network sites: a study with Arab and European samples
منشور في 2024"…These concerns have sparked a growing demand for SNS to introduce changes to their business model and offer features that prioritize users’ wellbeing, even if it means introducing fees to users. …"
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Database design patterns. (c2011)
منشور في 2011احصل على النص الكامل
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masterThesis -
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Bioinspired design of redox-active ligands for multielectron catalysis
منشور في 2015"…In a broader sense, these findings highlight the significance of electronic structure considerations in the design of effective electron–hole reservoirs for multielectron transformations.…"
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Courtyard’ design as a sustainable tool for classrooms’ lighting and thermal performance
منشور في 2023"…Finally, the 2X courtyard case had the best threshold glare level for the investigation room at roughly 212.48cd/m2, with significant difference from the other cases. This study can help in designing sustainable schools.…"
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Exploring AI Conversational Chatbot UX Design: Insights from High School
منشور في 2025"…Advancements in state-of-the-art models and algorithms for chatbots have significantly driven the growth and evolution of human–computer interaction (HCI) in recent years. …"
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Developing a Framework for Evaluating Accessibility Density and Coverage
منشور في 2015احصل على النص الكامل
doctoralThesis