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The Use of the Gene Expression Omnibus (GEO) Database to Study Gene Expression and Methylation Patterns in Cases of Preterm Birth and Associated Diseases
منشور في 2023"…<h3>Objective</h3> <p>Analysis of gene expression and methylation patterns in preterm births (PTB) and associated diseases from microarray data using the Gene Expression Omnibus (GEO) database. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Characteristics and comparisons of acute stroke in “recovered" to “active COVID-19 and “pre-pandemic” in Qatar database
منشور في 2022"…Large vessel disease and cardioembolic disease was significantly higher in CS compared to PPS or RCS. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Parkinson’s disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes
منشور في 2024"…<p dir="ltr">Genome-wide association studies suggest significant overlaps in Parkinson’s disease (PD) and schizophrenia (SZ) risks, but the underlying mechanisms remain elusive. …"
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The efficacy of colchicine in the management of coronavirus disease 2019
منشور في 2020"…If colchicine proved to be effective, it would be a significant milestone in the management of COVID-19, a disease with limited available therapeutic options.…"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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In-Hospital Outcomes and Temporal Trends of Surgical Versus Intravascular Ultrasound–Guided Endovascular Interventions for Femoropopliteal Disease
منشور في 2025"…This study aims to compare in-hospital outcomes and trends of surgical versus IVUS-guided EVI for femoropopliteal disease. MethodsThe National Inpatient Sample database (2016-2021) was analyzed. …"
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Evaluation of Neuro Images for the Diagnosis of Alzheimer's Disease Using Deep Learning Neural Network
منشور في 2022"…A novel and enhanced CAD system based on a convolutional neural network (CNN) is formulated to address this issue, capable of discriminating normal control from Alzheimer's disease patients. The proposed approach is evaluated using the 18FDG-PET images of 855 patients, including 635 normal control and 220 Alzheimer's disease patients from the ADNI database. …"
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Hepatitis serology predicts tumor and liver-disease characteristics but not prognosis after resection of hepatocellular carcinoma
منشور في 2004"…Using a multicenter international database, we identified 446 patients with complete HBV and HCV serology. …"
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Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review
منشور في 2024"…<h3>Background and Aims</h3><p dir="ltr">Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. …"
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Prevalence and global trends of polypharmacy in patients with chronic kidney disease: A systematic review and meta-analysis
منشور في 2023"…<h3>Background and objectives</h3><p dir="ltr"> Polypharmacy and chronic kidney disease (CKD) are becoming increasingly common due to an ageing population and the rise of multimorbidity. …"
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The Association Between Religiosity, Spirituality, and Medication Adherence Among Patients with Cardiovascular Diseases: A Systematic Review of the Literature
منشور في 2022"…<p>This systematic review aimed to summarize the literature on the relationship between religiosity or spirituality (R/S) and medication adherence among patients with cardiovascular diseases (CVDs) and to describe the nature and extent of the studies evaluating this relationship. …"
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Can AI Help in Screening Viral and COVID-19 Pneumonia?
منشور في 2020"…<p>Coronavirus disease (COVID-19) is a pandemic disease, which has already caused thousands of causalities and infected several millions of people worldwide. …"