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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Mechanical Properties of Sustainable High Strength High Ductility PE-ECC at Elevated Temperatures
منشور في 2022احصل على النص الكامل
doctoralThesis -
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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احصل على النص الكامل
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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احصل على النص الكامل
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Finite Element Modelling of FRCM-Confined RC Columns Exposed to Fire
منشور في 2023احصل على النص الكامل
doctoralThesis -
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Western diet induces mild metabolic impairment and aggravates neuropathology in an experimental mouse model of traumatic brain injury
منشور في 2024"…Results showed that while WD significantly increased fat percentage and elevated plasma cholesterol, there was no change in blood glucose level or body weight, indicating an early stage of MetS. …"
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احصل على النص الكامل
احصل على النص الكامل
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Investigating the Role of Acetyl-CoA Synthetase Short Chain Family Member 2 (ACSS2) in Inflammatory Bowel Disease: Expression in Clinical Samples and Insights from In Vitro Models
منشور في 2025"…In this study, immunohistochemistry of colon samples from UC patients revealed significantly elevated expression and nuclear localization of ACSS2 in inflamed tissues compared to non-inflamed regions, suggesting its involvement in IBD pathogenesis. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
masterThesis -
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Experimental Verification of Low-Pressure Kinetics Model for Direct Synthesis of Dimethyl Carbonate Over CeO<sub>2</sub> Catalyst
منشور في 2024"…However, this synthetic route has faced significant thermodynamic limitations, even at elevated pressure conditions. …"
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Advanced Techniques for Predicting the Future Progression of Type 2 Diabetes
منشور في 2020"…<p dir="ltr">Diabetes is a costly and burdensome metabolic disorder that occurs due to the elevation of glucose levels in the bloodstream. If it goes unchecked for an extended period, it can lead to the damage of different body organs and develop life-threatening health complications. …"
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Long Term HbA1c Prediction Using Multi-Stage CGM Data Analysis
منشور في 2021"…<p dir="ltr">The glycated hemoglobin (HbA1c) is regarded as an essential biomarker for diabetes management. Having an elevated HbA1c level significantly increases the risk of developing diabetes-related health complications. …"
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