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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Emission taxes when pollution depends on location
منشور في 2012"…It is well known that an efficient pollution taxation scheme should charge each source according to its specific marginal contribution to social damages. Despite significant advances in environmental assessment, geographic information systems and data analysis, this requirement would impose technical, informational and administrative expenses that most regulators – notably in developing countries – seem unable to afford. …"
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
منشور في 2025احصل على النص الكامل
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Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer
منشور في 2016"…Results: Independent factors significantly associated with an R1 resection margin included an upper third esophageal tumor location, preoperative malnutrition, and pathological stage III. …"
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Central air conditioning, air pollution and housing location: evidence from Lebanon
منشور في 2022"…The data set includes information about air pollution concentrations, dwellings’ characteristics, geographic features and location characteristics. …"
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Effect of Pilot-Points Location on Model Calibration: Application to the Northern Karst Aquifer of Qatar
منشور في 2019"…The model was calibrated using the parameter estimation and uncertainty analysis (PEST) package employing historical data of groundwater levels. The effect of the number and locations of pilot-points was examined by running the model using a variable numbers of points and several perturbations of locations. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Detecting location of construction defects in drilled shafts using frequency tomography analysis of cross-hole sonic logging
منشور في 2014"…It uses changes in color of the frequency amplitude of the received signal in the location of defects. The method transfers time-domain data to frequency-domain data of the signals propagated between the tubes using Fast Fourier Transform (FFT). …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Integrating data collection optimization into pavement management systems
منشور في 2017"…This paper describes a method for using location data to optimize the routing of pavement data collection vehicles. …"
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An integrated data-centric innovations strategy for tackling road safety in Qatar
منشور في 2015"…This strategy is based on utilizing distributed data and connected devices to deliver intelligent user-centric services and applications that will tackle different problems contributing to road accidents in Qatar and the region. …"
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Communication-efficient hierarchical federated learning for IoT heterogeneous systems with imbalanced data
منشور في 2022"…<p dir="ltr">Federated Learning (FL) is a distributed learning methodology that allows multiple nodes to cooperatively train a deep learning model, without the need to share their local data. It is a promising solution for telemonitoring systems that demand intensive data collection, for detection, classification, and prediction of future events, from different locations while maintaining a strict privacy constraint. …"