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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Customer Service and Satisfaction in the three main Airports of the United Arab Emirates
منشور في 2007"…This indicates that Airport travelers are only going to increase going forward. To begin with, the UAE's environment is studied to test the main needs, demands and necessities of the country's aviation industry. …"
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The Grid Iron Patterns & Detached Villas as the Main Drivers of Sharjah City’s Urban Sprawl
منشور في 2021"…This rapid growth coincided with two phenomena worthy of attention, the first being the conjunction of this growth with the significant decline in residential density, and the second with the phenomenon of the increase in the proportion of non-durable residential lands, which reached 49% (DTPS, 1998) of the total land allocated to citizens. …"
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Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy
منشور في 2021"…This study aims to investigate whether DCM is associated with changes in cyclic adenosine 3′-5′ monophosphate (cAMP) signaling, particularly cyclic nucleotide phosphodiesterases (PDEs). Main methods Type 1 diabetes (T1D) was induced in rats by streptozotocin (STZ, 65 mg/kg) injection. …"
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Enhancing the Main Contractor-Subcontractor trusting relationship in the United Arab Emirates: A strategic approach to rebuilding trust in complex construction projects
منشور في 2017"…After this crisis, adversarial relationships and trust issues between subcontractors and main contractors have increased, therefore, it has become necessary to rebuild trust between them. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Triple helix components supporting STEM education to increase future STEM careers in the United Arab Emirates
منشور في 2023"…Increasing communication between government schools, universities, and industry can benefit STEM education programs and STEM careers. …"
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Increasing consultant-level staffing as a proportion of overall physician coverage improves emergency department length of stay targets
منشور في 2021"…</p><h3>Conclusions</h3><p dir="ltr">At the study site, in models that adjusted for overall on-duty EP numbers as well as myriad other operational factors, increasing numbers of on-duty Consultants was associated with a statistically and operationally significant reduction in ED LOS.…"
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Increased Frequency of Severe Hypoglycemia with the Modified-Release Gliclazide Compared to Glimepiride in Diabetic Older Adults; Propensity Score-Adjusted Analysis
منشور في 2022"…<h3>Objective</h3><p dir="ltr">The main aim is to compare the risk of severe hypoglycemia associated with the modified-release (MR) gliclazide against glimepiride in diabetic older adults. …"
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Walking around the preferred speed: examination of metabolic, perceptual, spatiotemporal and stability parameters
منشور في 2024"…While metabolic, perceptual and spatiotemporal values were sensitive to the smallest change in speed (i.e., 0.5 km·h<sup>−1)</sup>, a significant increase in the rate of carbohydrate oxidation and decrease in % fat oxidation were only observed at speeds above PWS. …"
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Impact of the positive pressure valve on vascular access device occlusions and bloodstream infections
منشور في 2009"…These types of devices have been shown to significantly decrease VAD occlusion rates by 8.2%, when compared to a standard connector device (Jacobs et al., 2004). …"
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Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
منشور في 2022"…These knockout zebrafish displayed significant morphological heart alterations related to a significant decrease in ventricular and atrial diameters at systolic and diastolic states at the larval stages. …"